The Individual Effect of Surfactants on The Penetration of Glimepiride Transdermal Patches Using Dibutylpthalate as a Plasticizer

  • Mounika P Gautham College of Pharmacy
  • Rinku mathappan Gautham College of Pharmacy
  • Sukriti Vishwas Gautham College of Pharmacy
Keywords: Glimepiride, Eudragit E -100, Surfactants, Matrix, Permeation

Abstract

Objective
Glimepiride is an anti-diabetic drug with shorter half-life of 5 hrs. Glimepiride penetration into skin is difficulty. To study effects the penetration of glimepiride using different surfactants using dibutylpthalate.

Methods
Glimepiride transdermal Patches are prepared by using solvent casting method.  Eudragit E -100, Polysorbate 80, Polysorbate 60 are used as a penetration enhancers. Dibutylpthalate acts as a plasticizer for the penetration enhancement.

Results
The present study was to formulate and evaluate transdermal drug delivery system of Glimepiride. Results were evaluated for Thickness, Tensile strength, Folding endurance, and Drug content and In vitro penetration study was performed by using Franz diffusion cell. The drug content in transdermal patch F-1 shows 98,F-2 shows 93, F-3 shows 92.the drug permeation through matrix membrane shows good release with Eudragit E-100 copolymer and surfactant SLS. In comparison with three surfactants SLS gives good release for glimepiride with Eudragit E-100 matrix membrane.

Conclusion
From the results glimepiride with SLS anionic surfactant shows good penetration. Dibutylpthalate acts a plasticizer which improves the penetration of glimepiride.

Author Biographies

Mounika P, Gautham College of Pharmacy

Department of Pharmaceutics
Gautham College of Pharmacy, Bangalore – 560032

Rinku mathappan, Gautham College of Pharmacy

Department of Pharmaceutics
Gautham College of Pharmacy Bangalore – 560032

Sukriti Vishwas, Gautham College of Pharmacy

Department of Pharmacology
Gautham College of Pharmacy, Bangalore – 560032

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Published
2019-07-01
How to Cite
[1]
P, M., mathappan, R. and Vishwas, S. 2019. The Individual Effect of Surfactants on The Penetration of Glimepiride Transdermal Patches Using Dibutylpthalate as a Plasticizer. PharmaTutor. 7, 7 (Jul. 2019), 14-17.
Section
Articles