Anti-Anemic Activity of Hydro-Alcoholic Extract Seeds of Foeniculum vulgare in Phenylhydrazine Induced Anemic Rats

  • Chandrakanta Kushwah Modern institute of Pharmaceutical Sciences
  • Ankur Joshi Modern institute of Pharmaceutical Sciences
  • Deepanshu Gupta Modern institute of Pharmaceutical Sciences
  • Sapna Malviya Modern institute of Pharmaceutical Sciences
  • Anil Kharia Modern institute of Pharmaceutical Sciences
Keywords: Anemia, anti-anemic activity, hydro-alcoholic extract, Foeniculum vulgare, Vit. B12

Abstract

The main objective of this research was to evaluate the anti-anemic activity in hydro-alcoholic extract of seeds of Foeniculum vulgare in phenylhydrazine induced anemic rats. Phenylhydrazine (60mg/kg) was given intraperitoneally in rats for two days to induce anemia. The animals were divided into 5 groups of 6 animals each. Group 1 was known as normal control group, Group 2 was known as anemic control group, Group 3 was known as standard reference control group given with Vit. B12, Group 4 was known as test control-I given with 100mg/kg of hydro-alcoholic extract of seeds of Foeniculum vulgare, Group 5 was known as test control-II given with 200mg/kg of hydro-alcoholic extract of seeds of Foeniculum vulgare. All the test drugs were given for 28 days through oral route once in a day. On 29th day blood was taken out through tail puncture and was subjected to the determination of RBC, Hb and percentage Haematocrit. Both the hydro-alcoholic seeds extract of Foeniculum vulgare and Vit. B12 significantly increase the HB, RBC & percentage Haematocrit level which shows that Foeniculum vulgare seeds exhibits the anti-anemic activity.

Author Biographies

Chandrakanta Kushwah, Modern institute of Pharmaceutical Sciences

Department of pharmacy
Modern institute of Pharmaceutical Sciences,
Indore, Madhya Pradesh, India

Ankur Joshi, Modern institute of Pharmaceutical Sciences

Department of pharmacy
Modern institute of Pharmaceutical Sciences,
Indore, Madhya Pradesh, India

Deepanshu Gupta, Modern institute of Pharmaceutical Sciences

Department of pharmacy
Modern institute of Pharmaceutical Sciences,
Indore, Madhya Pradesh, India

Sapna Malviya, Modern institute of Pharmaceutical Sciences

Department of pharmacy
Modern institute of Pharmaceutical Sciences,
Indore, Madhya Pradesh, India

Anil Kharia, Modern institute of Pharmaceutical Sciences

Department of pharmacy
Modern institute of Pharmaceutical Sciences,
Indore, Madhya Pradesh, India

References

Gupta Deepanshu, C. Kushwah, A. Joshi, K. Malviya, S. Malviya, A. Kharia (2018) “Anti-anemic activity of hydro-alcoholic leaf extract of brassica oleracea var in phenylhydrazine induced anemic rats”; Asian Journal of Pharmaceutical Education and Research; 7(2); 86-91

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Hussain Aafreen et al (2017); “Anti-anemic Activity of Seeds of Trigonella Foenum-graecum in Male Albino Rats”; J Pharm Biomed Sci; 6(11); 608-612.

Joshi Ankur, Soni Priyanka, Vyas Narendra, Khan Javed, Malviya Sapna, Kharia Anil (2017); “Anti-anemic activity of hydro alcoholic leaf extract of Aegle marmelos in phenylhydrazine induced anemic rats”; International Journal of Current Research; 9(4); 48928-48931

Joshi Ankur et al (2017) “Anti-anemic activity of hydro alcoholic leaf extract of Tamarindus Indica in phenylhydrazine induced anemic rats”; Journal of harmonized research in applied sciences; 5(3); 132-135.

Khandelwal K.R. (2013) “Practical Pharmacognosy”, 22nd ed., Nirali prakashan, Pune, 149-156.

Mohan Harsh (2005); “Textbook of pathology”; 5th edition; Jaypee Brothers, Medical publishers (p) ltd., New Delhi; 133.

Tortora J. Gerard, Derrickson Bryan (2015); “Anatomy & physiology”, 13th ed., Indian edition, Wiley India pvt. Ltd., New Delhi; 603-623.

Published
2018-07-01
How to Cite
[1]
Kushwah, C., Joshi, A., Gupta, D., Malviya, S. and Kharia, A. 2018. Anti-Anemic Activity of Hydro-Alcoholic Extract Seeds of Foeniculum vulgare in Phenylhydrazine Induced Anemic Rats. PharmaTutor. 6, 7 (Jul. 2018), 32-34. DOI:https://doi.org/10.29161/PT.v6.i7.2018.32.
Section
Articles

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