Formulation and Evaluation of Bilayered Tablets of Nifedipine as Immediate Release and Atenolol as Sustained Released Tablet
Abstract
Objective: The objective of the present study was to develop Bilayered tablets of Nifedipine and atenolol. Bilayered tablet contains two layers. We can formulate first layer into immediate release and second layer into sustained release for desired action. Nifedipine have half-life 2hrs make the drug suitable for immediate release. Atenolol have half-life 6-7hrs make the drug suitable for sustained release.
Methods: In this formulation using super disintegrants for immediate release, acacia and ethyl cellulose as polymers for sustained release. Tablets were prepared by wet granulation method. In this study Bilayered tablets of Nifedipine and Atenolol tablets were evaluated for weight variation, hardness, thickness, drug content and In-vitro studies.
Results: Bi-layer tablet is suitable for sequential release of two drugs in combination, separate to incompatible substances and also for immediate release as initial dose and sustained release as maintenance dose. In Immediate release formulation, IR-F-3 formulation gives 98% release within 15min. For sustained effect SR-F-3, SR-F-1 gives 98% release within 8-9hrs. SR-F-2 gives 99% release within 10-11hrs for a longer period of time.
Conclusion: The combination of IF-3 and SR-F-2 suitable for formulation. This formulation is used for Bilayered tablet to combine with sustained released tablet. The evaluation parameters were estimated.
References
Abebea A, Akselib I, Sprockela O, Kottalaa N, Cuitino AM.(2014); Review of bilayer tablet technology; Int J Pharm; 461(1-2); 549-58.
Albadry, A. A., W. K. Ali, F. A. Al-saady (2017); Formulation and Evaluation of Prochlorperazine Maleate Sustained Release Floating Tablet. International Journal of Pharmacy and Pharmaceutical Sciences; 9(2); 89-98
Department of Health Statistics and Informatics. Causes of death 2008: data sources and methods; Geneva: World Health Organization; 2008.
Divya.A, K.Kavitha (2011); Bilayered tablet technology: An over review; Journal of applied pharmaceutical science ; 1(8) ; 43-47
Fox CS (2010) ; Cardiovascular disease risk factors, Type 2 diabetes mellitus, and the Framingham heart study; Trends Cardiovasc Med ; 20(3); 90-95.
Garg R, Gupta GD. (2009); Preparation and evaluation of gastroretentive floating tablets of silymarin; Chem Pharm Bull ;57(6); 545-549.
Guguloth M, Bomma R, Veerabrahma K. (2011); Development of sustained release floating drug delivery system for norfloxacin: in vitro and in vivo evaluation; PDA J Pharm SciTechnol ; 65(3); 198-206.
He W, Li Y, Zhang R, Wu Z, Yin L. (2014); Gastro-floating bilayer tablets for the sustained release of metformin and immediate release of pioglitazone: Preparation and in vitro/in vivo evaluation; Int J Pharm ; 476(1-2); 223-31.
Kaushik Mukherjee, Subrata Chakraborty, Biswanath Sa (2015); Quick /slow biphasic release of a poorly water soluble antidiabetic drug from bi-layer tablets; Int J Pharm Pharm Sci; 7(11); 250-258
Lavie CJ, Milani RV, Ventura HO (2009); Obesity and cardiovascular disease risk factor, paradox, and impact of weight loss; J Am CollCardiol; 53(21); 1925-32.
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Rohani HA, et al. (2012); A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the global burden of disease study 2010; The Lancet ; 380(9859); 2224-2260.
Nakagawa T, Kondo S, Sasai Y, Kuzuya M. (2006); Preparation of floating drug delivery system by plasma technique; Chem Pharm Bull ; 54(4); 514-8.
Pawar VK, Kansal S, Garg G, Awasthi R, Singodia D, Kulkarni GT. (2011); Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems. Drug Deliv ; 18(2); 97-110.
