Formulation and evaluation of microencapsulated Glimepiride produced by the emulsion - solvent evaporation method
The objective of the present investigation was to formulate and evaluate microencapsulated Glimepiride produced by the emulsion - solvent evaporation method. Microparticles were prepared using Eudragit RLPO by emulsion solvent evaporation and characterized for their micromeritic properties, encapsulation efficiency, particle size, In vitro release studies were performed in phosphate buffer (pH 7.4). The resulting microparticles obtained by solvent evaporation method were free flowinging nature. The mean particle size of microparticles ranges from 140.40 - 173.90 μm and encapsulation efficiency ranges from 90.46 – 93.09%. Eudragit RLPO microparticles containing Glimepiride could be prepared successfully by using an emulsion solvent evaporation technique, which will not only sustain the release of drug but also manage complicacy of the diabetes in a better manner.
Behera B.C, Sahoo S. K, Dhal S, Barik B B, Gupta BK (2008); Characterization of Glipizide-Loaded Polymethacrylate Microspheres Prepared By an Emulsion Solvent Evaporation Method. Tropical Journal of Pharmaceutical Research; 7(1); 879-885.
Bravo S.A, Lamas M.C, Salamon CJ. (2002); In-Vitro Studies of diclofenac Sodium controlled release from biopolymeric hydrophilic matrices; J Pharma pharm Sci; 5(3); 213- 219.
Chowdary K.P, Rao YS. (2003); Design and in vitro and in vivo evaluation of mucoadhesive microcapsules of glipizide for oral controlled release: A technical note. AAPS PharmaSciTech; 4(3); 87-92.
Davis S.N. (2004); The role of glimepiride in the effective management of Type 2 diabetes; J Diabetes Complications; 18(6); 367-376.
Davis, Stephen N. (2005); chapter-60; Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas". In Brunton, Laurence L.; Lazo, John S.; Parker, Keith L. (eds.). Goodman & Gilman's the Pharmacological Basis of Therapeutics. New York: McGraw-Hill. 1636.
Dashora K, Saraf S. (2006); Effect of processing variables on micro particulate system of aceclofenac; Pak J Pharm Sci; 19(1); 6-10.
Hamaguchi T, Tokunaga K et al. (2004); Efficacy of glimepiride in type 2 diabetic patients treated with glibenclamide; Diabetes Res Clin Pract; 66(1); S129-132.
K.P.R Chowdary, K.Ravi Shankar, S.V.V. Subrahmanyam (2014); Recent Research on Microspheres - A Review; Journal of Global Trends in Pharmaceutical Sciences; 5(2); 1557-1566.
Lin WJ and Wu TL. (1999); Modification of the initial release of a highly water soluble drug from ethyl cellulose microspheres prepared by emulsion solvent evaporation method; Journal of Microencapsulation; 16(5); 639-646
Nissen SE, Nicholls SJ, Wolski K, Nesto R, Kupfer S, Perez A et al., (2008) ; Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial; JAMA; 299(13); 1561-1573.
Pandey A, Singh BV. (2011); Formulation development & optimization of Glimepiride microspheres using ionotropic gelation technique; Pharmacia; 1; 67-72.
Sai Kishore V, Gopala krishna murthy TE, Pavan Kumar A, Satyanaryana J. (2011); Formulation and evaluation of mucoadhesive microcapsules of glimepiride. Res J Pharm Tech; 4(5); 739-743.
Sahoo SK, Mallick AA, Barik BB, Senapati PC. (2005); Formulation and in vitro Evaluation of Eudragit Microspheres of Stavudine. Tropical Journal of Pharmaceutical Research; 4(1); 369-375.
Haznedar S, Dortunc B. (2004); Preparation and in vitro evaluation of Eudragit microspheres containing acetazolamide; Int J Pharm; 269(1); 131-140.