Formulation, Evaluation of Polyherbal Solid Dosage Form and Study of Its Antimicrobial and Antioxidant Activity
Aim and objective: The primary aim of the study is to formulate, standardize and evaluate the polyherbal (Murraya koenigii, Zingiber officinale,n Syzygium cumini, Phyllanthus emblica, Moringa oleifera, Azadirachta indica, Citrous limon) solid dosage form for systemic diseases. Methodology: The polyherbal solid, Dosage form was formulated by filling the polyherbal powder mixture into the hard gelatin capsules, standardized as per WHO guidelines of quality standardization. It was evaluated for antioxidant parameters (DPPH and ABTS assays) and Antimicrobial activity. Results: Pharmaceutical parameters i.e. weight variation; moisture analysis and drug content are within I.P limit. Dissolution studies reveal that the release of maximum drugs (91%) at 120 minutes. The DPPH assay and ABTS assay activity of the polyherbal extract is found to be close to the standard drugs. Antimicrobial activity of polyherbal extract showed zone of inhibition 34mm for E-coli and 12 mm for Aspergillus Niger. The polyherbal drugs are less effective against rest of the microorganisms.
Aslan M, Orhan N, Orhan DD, Ergun F (2010); Hypoglycemic activity and antioxidant potential of some medicinal plants traditionally used in Turkey for diabetes; J Ethnopharmacol; 128(2); 384-389
Boopathi T, Gopalasatheeskumar K, Parthiban S, Sangeetha G, Thanga Kokila M, Manimaran T (2017); Evaluation of Antimicrobial Activity of Tecoma Stans and Muntingia Calabura; World Journal of Pharmaceutical Research; 6(3); 617-627
Chui SH, Wong YH, Chio HI, Fong MY, Chiu YM, Szeto YT, Vong WT, Lam CW (2013); Study of heavy metal poisoning in frequent users of Chinese medicines in Hong; Kong and Macau; Phyt-other Res; 27(6); 859-863
Dahanukar SA, Thatte UM. Bombay: Popular Prakashan; 1989. Ayurveda Revisited.
Gopalasatheeskumar K, Parthiban S, Manimaran T, Boopathi T (2017); Phytochemical Screening on Various Extracts (Benzene, Ethanolic and Aqueous) of Stem Parts of Zanthoxylum Rhetsa (Roxb.) Dc; International Journal of Universal Pharmacy and Bio Sciences; 6(2); 79-91
Kopleman SH, Nguyen Pho A, Zito WS, Muller FX, Augsburger LL (2001); Selected physical and chemical properties of commercial Hypericum perforatum extracts relevant for formulated product quality and performance; AAPS PharmSci; 3(4); 1–18
Kshirsagar M, Magno AC. USA: Lotus Press; (2011); Ayurveda-A quick reference handbook.
Chawla R, Kumar V, Sharma RK, Arora R (2013); Evidence based herbal drug standardization approach in coping with challenges of holistic management of diabetes, a dreadful lifestyle disorder of 21st century; J Diabetes MetabDisord; 12(1); 35
Saravanan J, Neethu Devasia, Gopalasatheeskumar K, Sanish Devan V, Thanga Kokila K, Sanjay M (2018); Anti-Inflammatory, Antipyretic And Antibacterial Study of Kabasura kudineer choornam; International Journal of Current Advanced Research; 7(2); 9992-9997.
Satyanarayan S, Kasinatha S, Chaturvedi G (1998); CharakaSamhita. Chaukhamba Bharati Academy, Varanasi, India.
Savrikar SS, Ravishankar B, Bhaishajya Kalpanaa (2010); The Ayurvedic pharmaceutics – an overview; Afr J Tradit Complement Altern Med; 7(3); 174-184