Formulation, Evaluation of Polyherbal Solid Dosage Form and Study of Its Antimicrobial and Antioxidant Activity
Abstract
Aim and objective: The primary aim of the study is to formulate, standardize and evaluate the polyherbal (Murraya koenigii, Zingiber officinale,n Syzygium cumini, Phyllanthus emblica, Moringa oleifera, Azadirachta indica, Citrous limon) solid dosage form for systemic diseases. Methodology: The polyherbal solid, Dosage form was formulated by filling the polyherbal powder mixture into the hard gelatin capsules, standardized as per WHO guidelines of quality standardization. It was evaluated for antioxidant parameters (DPPH and ABTS assays) and Antimicrobial activity. Results: Pharmaceutical parameters i.e. weight variation; moisture analysis and drug content are within I.P limit. Dissolution studies reveal that the release of maximum drugs (91%) at 120 minutes. The DPPH assay and ABTS assay activity of the polyherbal extract is found to be close to the standard drugs. Antimicrobial activity of polyherbal extract showed zone of inhibition 34mm for E-coli and 12 mm for Aspergillus Niger. The polyherbal drugs are less effective against rest of the microorganisms.
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