Hepatitis: Crisis of People

  • A Suman Pratishta Institute of Pharmaceutical Sciences
  • M Nagavamshidhar Pratishta Institute of Pharmaceutical Sciences
  • J Srikanth Pratishta Institute of Pharmaceutical Sciences
  • Z L Qadrie Pratishta Institute of Pharmaceutical Sciences
Keywords: Liver, Hepatitis, Hepatocellular Carcinoma, Pathophysiology


Hepatitis is a viral infection which can leads to the inflammation of liver. The injury is occurred to the liver due to the inflammation of hepatic cells. The auto immune hepatitis occurred when the body makes antibodies against its own hepatocytes (or) liver cells. Hepatitis is an inflammation that can be shelf limited or can progress to fibrosis, liver cancer, and cirrhosis. The hepatitis word comes from the ancient Greek, it means, heap-liver cities: inflammation the first hepatitis discussed in 1963 when Dr Baruch Blumberg discovered an antigen that detected in blood samples. HAV severity is increased with the age; this is lead to outbreaks of HAV. HAV vaccination was developed in 1990s; it is thermo-stable and acid resistant. All viruses are classified according to their virion properties like morphology, physiochemical properties and physical properties, genome, lipids, proteins, carbohydrates, genome organization and replication. HBV is a global health problem that can leads to the liver cirrhosis and hepatocellular carcinoma. The majority of liver transplantations occurred due to the HCV infection. The pathophysiology is not completely understood, the virus is reached to the liver but exact mechanism not known, the HVE replicated in Gastro-intestinal tract it before enter to the liver. The study was mainly done because of the common people have lakh of knowledge on about hepatitis, they are suffered a lot due to this disease by doing this type of reviews reveals that how the common peoples are suffered, how to improve health information and communication to people in health care system. Health care team and system improve the information provided to people regarding the current issues of diseases, treatments and preventing measures based on this type of reviews.

Author Biographies

A Suman, Pratishta Institute of Pharmaceutical Sciences

Department of Pharmacy Practice,
Pratishta Institute of Pharmaceutical Sciences,
Suryapet, Telangana, India

M Nagavamshidhar, Pratishta Institute of Pharmaceutical Sciences

Department of Pharmacy Practice,
Pratishta Institute of Pharmaceutical Sciences,
Suryapet, Telangana, India

J Srikanth, Pratishta Institute of Pharmaceutical Sciences

Department of Pharmacy Practice,
Pratishta Institute of Pharmaceutical Sciences,
Suryapet, Telangana, India

Z L Qadrie, Pratishta Institute of Pharmaceutical Sciences

Department of Pharmacy Practice,
Pratishta Institute of Pharmaceutical Sciences,
Suryapet, Telangana, India


Abbas Z, Afzal R (2013); Life cycle and pathogenesis of hepatitis D virus; A review. World J Hepatol; 5(12); 666-675

Ahmed A, Ali IA, Ghazal H, Fazili J, Nusrat S. (2015); Mystery of hepatitis e virus; recent advances in its diagnosis and management; Int J Hepatol.; 872431.

Arvind R Murali, Vikram Kowal, and Saurabh Chawla. Chronic hepatitis E (2015); A brief review, World J Hepatol. ; 7(19); 2194–2201.

Blanca San José Montano (2016), Using the journal BMJ case reports to promote the publication of clinical case reports; J Med libr Assc; 104(4); 325-327

Chan Ran You, Sung Won Lee, Jeong Won Jang, and Seung Kew Yoon (2014); Update on hepatitis B virus infection, World J Gastroenterol.; 20(37); 13293–13305.

Chou R, Hartung D, Rahman B et al (2012); Treatment for Hepatitis C Virus Infection in Adults; Comparative Effectiveness Reviews No. 76; Agency for Healthcare Research and Quality (US); www.ahrq.gov

Charlotte M. Nijskens, Suzan D. Pas, Annemiek A. van der Eijk, Robert A. de Man (2015); Hepatitis E in Europe; diagnosis and treatment; EMJ Gastroenterol ; 4(1); 121-127.

Carolina Alves, Cristina Branco, and Celso Cunha (2013); Hepatitis Delta Virus; A Peculiar Virus; Advances in Virology; vol. 2013; Article ID 560105; 11 pages

Dastgerdi ES1, Herbers U, Tacke F. (2012); Molecular and clinical aspects of hepatitis D virus infections. World J Virol.; 1(3); 71-78

Elgouhari HM, Abu-Rajab Tamimi TI, Carey WD (2008); Hepatitis B virus infection; understanding its epidemiology, course, and diagnosis., Cleveland clinic journal of medicine; 75(12); 881-889.

Franco E, Meleleo C, Serino L, Sorbara D, Zaratti L. (2012); Hepatitis A: Epidemiology and prevention in developing countries, World J Hepatol.; 4(3); 68-73.

Goldberg DS, FrenchB et al (2016); Liver transplant center variability in accepting organ offers and its impact on patient survival; Journal of Hepatology; 64(4); 843-851.

Hoofnagle JH, Nelson KE, Purcell RH (2012); Current Concepts: Hepatitis E; The New England Journal of Medicine; 367(13); 1237-1244.






Jake Liang (2009); Hepatitis B: The virus and disease; Hepatology; 49(5suppl); s13-s21.

James Smith (2001); A Review of Hepatitis E Virus; Journal of Food Protection; 64(4); 572-586 .

James M. Hughes, Mary E. Wilson, Eyasu H. Teshale, Dale J. Hu, Scott D. Holmberg (2010); The Two Faces of Hepatitis E Virus; Clinical Infectious Diseases; 51(3); 328–334

Jennifer A. Cuthbert. (2001); Hepatitis A; Old and New; Clinical Microbial Reviews; 14(1); 38-58.

Jules L Dienslag; Acute viral hepatitis; Harrisons principles of internal medicine; pg no 2004

Kamar N, Lhomme S, Abravanel F, Marion O, Peron JM, Alric L, Izopet J (2016); Treatment of HEV Infection in Patients with a Solid-Organ Transplant and Chronic Hepatitis. Viruses; 8(8); pii: E222

Kumar S, Subhadra S, Singh B, Panda BK. (2013); Hepatitis E virus; the current scenario; Int J Infect Dis.; 17(4); e228-233.

Nassim Kamar, Harry R. Dalton, (2014); Florence Abravanel, Jacques Izopet,Hepatitis E Virus Infection; Clin Microbiol Rev.; 27(1); 116–138.

Nikolaos Pyrsopoulos; Hepatitis B; https;//emedicine.medscape.com/article/177632-overview. Accessed from www.medscape.com.

Noureddin M, Gish R. (2014); Hepatitis delta; epidemiology, diagnosis and management 36 years after discovery, Curr Gastroenterol Rep.; 16(1); 365

Pallavi K, Sravani D, Durga S et al; Hepatitis Review on Current and Future Scenario; J In Silico In Vitro Pharmacol.; 2017; 3(1); 1-5

P. Husa, A. Linhartová, V. Němeček, L Husová (2005); Hepatitis D; Acta Virologica; 49(4); 219-225

Praveen k Roy; Hepatitis D: Available From: https://emedicine.medscape.com/article/178038-overview

Rakesh Aggarwal ,Shahid Jameel (2011); Hepatitis E; Hepatology; 54(6) ; 2218-2226

Hesham M. Elgouhari (2008); Hepatitis B virus infection: Understanding its epidemiology, course, and diagnosis; Cleveland clinic journal of medicine; 75(12); 881-889.

S Mohmammad, E Tahaei atl (2014); Prevalence of hepatitis D virus in hepatitis B virus infected patients referred to Taleghani hospital, Tehran, Iran; 7(3); 144-150

Sandra Rodriguez, William D. Carey (2013); Hepatitis E-An Evolving disease; Cleveland clinic; Accessed from http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/hepatology/hepatitis-e/

Severin Gudima, Jinhong Chang, Gloria Moraleda, Anna Azvolinsky, John Taylor (2002); Parameters of Human Hepatitis Delta Virus Genome Replication: the Quantity, Quality, and Intracellular Distribution of Viral Proteins and RNA; J. Virol.; 76(8); 3709-3719.

Shaina M. Lynch, George Y. Wu (2016); Hepatitis C Virus: A Review of Treatment Guidelines, Cost-effectiveness, and Access to Therapy; J Clin Transl Hepatol; 4(4); 310-319.

Shobha N. Joshi (2014); Hepatitis C Screening; Ochsner J. Winter; 14(4); 664–668.

Sultanik P, Pol S (2016); Hepatitis Delta Virus: Epidemiology, Natural Course and Treatment; J Infect Dis Ther 4(2); 271

T. Jake Liang (2009); Hepatitis B: The Virus and Disease; Hepatology; 49(5); S13–S21.

Tang CM et al. (2014); Management of chronic hepatitis B infection; World Journal of Gastroenterology; 20(20);6262-6278.

Thad wilkins, Jennifer K. Malcolm, Dimple Raina, Robert R. Schade (2010); Hepatitis C: Diagnosis and Treatment; American Family Physician.; 81(11); 1351-1357.

Trépo C, Chan HL, Lok A (2014); Hepatitis B virus infection; Lancet; 384(9959); 2053-2063

P. Vasickova, I. Psikal, P. Kralik, F. Widen, Z. Hubalek, I. Pavlik (2007); Hepatitis E virus: a review; Veterinarni Medicina; 52(9); 365-384 .

Vinay sundaram (2015); Management of chronic hepatitis B infection; BMJ; 351; h4263.

Vinod k Dhawan, https://emedicine.medscape.com/article/177792-overview



www.who.int.; epidemiology and statics of hepatitis D virus


www.whoint. WHO safety measure and guidelines of prevention of hepatitis.

Zhang J, Nguyen D, Hu KQ (2016); Chronic Hepatitis C Virus Infection; A Review of Current Direct-Acting Antiviral Treatment Strategies; N Am J Med Sci (Boston); 9(2); 47-54

How to Cite
Suman, A., Nagavamshidhar, M., Srikanth, J. and Qadrie, Z.L. 2018. Hepatitis: Crisis of People. PharmaTutor. 6, 8 (Aug. 2018), 31-37. DOI:https://doi.org/10.29161/PT.v6.i8.2018.31.

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