In Silico drug designing studies on Dengue Virus NS1 Protein

  • Balasubramanian Sathyamurthy Ramaiah College of Arts, Science and Commerce
  • H S Sushmitha Ramaiah College of Arts, Science and Commerce
Keywords: NS1 protein, Binding interaction, molecular docking, dengue

Abstract

The key proteins involved in causing dengue are seven major proteins, which are considered as major therapeutic targets for dengue drug development. Recent studies have reported positively for NS1 protein in dysregulation of causing dengue process in humans. Dragon fruit seed phytochemicals are reported to have antioxidant and antiviral properties. In the present study we studied binding efficiency of 11 compounds that are present in the dragon fruit seeds with NS1 Protein through Insilico methods. By our virtual screening and docking result, we found that the Compound A, Compound B and Compound C have highest binding affinity with the NS1 Protein and also we predicted the binding site amino acid residues and the nature of hydrogen bonding. However more invivo experimental validation of our results with animal models will enlighten the development of more potent drugs from these compounds for treatment of dengue.

Author Biographies

Balasubramanian Sathyamurthy, Ramaiah College of Arts, Science and Commerce

Department of Biochemistry,
Ramaiah College of Arts, Science and Commerce,
Bangalore, Karnataka, India

H S Sushmitha, Ramaiah College of Arts, Science and Commerce

Department of Biochemistry,
Ramaiah College of Arts, Science and Commerce,
Bangalore, Karnataka, India

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Published
2018-10-01
How to Cite
[1]
Sathyamurthy, B. and Sushmitha, H.S. 2018. In Silico drug designing studies on Dengue Virus NS1 Protein. PharmaTutor. 6, 10 (Oct. 2018), 31-36. DOI:https://doi.org/10.29161/PT.v6.i10.2018.31.
Section
Articles

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