http://www.pharmatutorjournal.com/index.php/pt/issue/feed PharmaTutor 2019-08-31T11:40:47+00:00 Dr. Sanjeev Acharya editor-in-chief@pharmatutor.org Open Journal Systems <p><span style="font-family: verdana,geneva,sans-serif;"><span style="font-family: georgia,serif;">The PharmaTutor&nbsp; <strong>(ISSN: 2347 - 7881)</strong> is a monthly published online journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences &amp; Lifesciences.<br></span></span></p> http://www.pharmatutorjournal.com/index.php/pt/article/view/696 Molecular Docking and Pharmacological Property Analysis of Antidiabetic Agents from Medicinal Plants of Bangladesh against Type II Diabetes: A Computational Approach 2019-08-31T11:40:47+00:00 Nazmul Islam Prottoy prottoy.bgeju@gmail.com Bishajit Sarkar prottoy.bgeju@gmail.com Asad Ullah prottoy.bgeju@gmail.com Sohana Hossain prottoy.bgeju@gmail.com Aisha Siddiqua Boby prottoy.bgeju@gmail.com Yusha Araf prottoy.bgeju@gmail.com <p class="rtejustify"><span style="font-family: verdana,geneva,sans-serif;">Diabetes Mellitus (DM) is a metabolic disorder which affects the people of almost all ethnic groups around the world severely. The effect of this disease involves lifelong suffering and has no permanent cure till now. Although different medications are available in the market but they are not accessible to every person due to their high cost, requirement of frequent administration and inability to alleviate diabetes permanently.&nbsp; Plant derived compounds are being commonly used by many people, specifically by those in rural areas of many countries as ayurvedic source of antidiabetic agents and these are more preferable to everyone due to their less toxicity and side effects. These compounds work by variety of mechanisms which involve different interactions between effective compounds and target proteins in the metabolic pathway. Molecular docking study helps in determining the interaction between specific ligands and receptors to specify the best lead that fits the target.&nbsp; This study has been designed to investigate the interactions with the aid of computational simulation tool between medicinal plant derived antidiabetic agents (Aegeline, Gallic Acid, Mangiferin and Quercetin) and a glucose metabolism regulatory target enzyme involved in type II diabetes, Glycogen Synthase Kinase-3 Beta (GSK3B) to assist potential antidiabetic drug search from natural source. </span></p> <p class="rtejustify"><span style="font-family: verdana,geneva,sans-serif;">ADME/T test assists in determining various physicochemical and pharmacological properties of lead molecules like their extent of adsorption inside the cell, extent of metabolism, solubility, blood brain barrier permeability, mutagenicity, carcinogenicity&nbsp;&nbsp; etc. which are the major prerequisites before marketing a drug. Quercetin performed well in overall experiment suggesting the best finding of the experiment.</span></p> <p class="rtejustify"><span style="font-family: verdana,geneva,sans-serif;">However, further in vitro/in vivo study is required to find out the best remedy of diabetes. </span></p> 2019-09-01T00:00:00+00:00 ##submission.copyrightStatement## http://www.pharmatutorjournal.com/index.php/pt/article/view/679 Formulation and evaluation studies of Atorvastatin calcium sustained release tablet 2019-08-31T11:40:47+00:00 Mohammad Sarowar Uddin pharmasarowar@gmail.com Md. Arafat jakir pharmasarowar@gmail.com Md. Shalauddin Millat millat404pharma@gmail.com Shafayet Ahmed Siddiqui sarowarsohel420@gmail.com <p>Atorvastatin calcium is a poorly water soluble compound marketed in Bangladesh under bio-waiver conditions. The present study aimed to develop formulation and drug excipients compatibility study of Atorvastatin calcium (50 mg) sustain release tablet and optimize the final formula. The tablet were formulated by direct compression method and the results obtained were extrapolated. Solid dispersion of Atorvastatin calcium was prepared by using Hydroxypropyl methyl cellulose, Methyl cellulose, Lactose, Guar gum, Xanthan gum &amp; Magnesium Stearate. The in vitro equivalence test was carried out in three different media. Test results were subjected to statistical analysis to compare the dissolution profiles. Other general quality parameters of these tablets such as weight variation, friability, thickness, hardness and disintegration time were also determined according to established protocols. Final formulation of solid dispersed Atorvastatin calcium revealed that successfully improvement of solubility as well as dissolution of Atorvastatin calcium in long time. This study could be very much helpful for better bioavailability of poorly water soluble drug avoiding first pass metabolism. Finally, we can claim that prepared tablets are proved to be promising dosage form for sustained drug delivery of Atorvastatin calcium by reducing dosing frequency and increasing the patient compliance.</p> 2019-09-01T00:00:00+00:00 ##submission.copyrightStatement## http://www.pharmatutorjournal.com/index.php/pt/article/view/666 A Review on Pharmacological Aspects Of Tagetes erecta Linn 2019-08-31T11:40:47+00:00 Navjeet Singh Navjeetnavi22g@gmail.com . Mrinal Navjeetnavi22g@gmail.com Rubal Thakur Navjeetnavi22g@gmail.com <p>Medicinal plants and derived medicine are widely used in traditional culture all over the world and they are becoming increasingly popular in modern society as natural alternatives to synthetic chemicals. <em>Tagetes erecta </em>Linn Known as “genda phool” (Marigold) belong to the family Astraceae, native to Mexico, Central America, Bolivia and Colombia. All parts of this plant used for medicinal purposes. It contained wide range of chemical constituents thiophenes, flavanoids, cartenoids, triterpenoids, oxycaroteniod and xanthophylls. This review article focus on the pharmacological actions like antibacterial, antifungal, antioxidant, hepatoprotective activity, wound healing property, cytotoxic and insecticidal activities. This review is a step to open insight for therapeutic efficacy of <em>Tagetes erecta.</em></p> 2019-09-01T00:00:00+00:00 ##submission.copyrightStatement## http://www.pharmatutorjournal.com/index.php/pt/article/view/698 A Review : Introduction of Effervescent Tablet and their Quality Control test 2019-08-31T11:40:47+00:00 Brijesh Dasvani brijeshdaswani@gmail.com Avani Khristi avani.khristi@paruluniversity.ac.in <p><span style="font-family: verdana,geneva,sans-serif;">Oral dosage forms are the best medicine administration way of taking medication, despite having some disadvantages compared with other methods like risk of slow absorption of the medicament, which can be overcome by administering the drug in liquid form, therefore, possibly allowing the use of a lower dosage. However, instability of many drugs in liquid dosage form limits its use. Effervescent technique can be used as alternate to develop a dosage form which can accelerate drug disintegration and dissolution, is usually applied in quick release preparations. Along with the development of new pharmaceutical technique, effervescent tablet are more and more extensively to adjust the behaviour of drug release, such as in sustained and controlled release preparations, pulsatile drug delivery systems, and so on.</span></p> 2019-09-01T00:00:00+00:00 ##submission.copyrightStatement## http://www.pharmatutorjournal.com/index.php/pt/article/view/697 UV Spectrophotometric Determination of Olmesartan Medoxomil in Pure and Pharmaceutical Formulation 2019-08-31T11:40:47+00:00 HARSHADA PANDIYA hspandiya@gmail.com K S RATHORE hspandiya@gmail.com <p><span style="font-family: verdana,geneva,sans-serif;">Olmesartan medoxomil (OM) is a new angiotensin II receptor antagonist agent. Olmesartan medoxomil is a prodrug, which, after ingestion, liberates the only active metabolite, olmesartan. Simple and sensitive method has been developed for determination of olmesartan medoxomil in both pure and pharmaceutical formulation. This method obeys Beer’s law in the concentration range of 15-55 µg/ml, exhibiting maximum absorption at 258.10 nm. In this method no interference from the common pharmaceutical excipients was observed. The developed and validated method was applied for the determination of olmesartan medoxomil in pharmaceutical dosage forms.</span></p> 2019-09-01T00:00:00+00:00 ##submission.copyrightStatement## http://www.pharmatutorjournal.com/index.php/pt/article/view/699 Hepatotoxicity and Hepatoprotective agents : A Mini review 2019-08-31T11:40:47+00:00 Mudasir Maqbool bhatmudasir.scholar@kashmiruniversity.net Shafiqa Rasool bhatmudasir.scholar@kashmiruniversity.net Mohmad Amin Dar bhatmudasir.scholar@kashmiruniversity.net Rabiah Bashir bhatmudasir.scholar@kashmiruniversity.net Misba Khan bhatmudasir.scholar@kashmiruniversity.net <p><span style="font-family: verdana,geneva,sans-serif;">The maintenance of a healthy liver is vital to overall health of the human beings. Since the liver is involved in almost all biochemical processes and there are many different diseases that will affect it. The liver is often abused by environmental toxins, which are eating habits, alcohol and overdose of certain drugs which can damage and weaken the liver and eventually lead to many diseases. Medicinal herbs are significant source of hepatoprotective drugs. Mono and poly-herbal preparations have been used in various liver disorders. According to one estimate, more than 700 mono and poly-herbal preparations in the form of decoction, tincture, tablets and capsules from more than 100 plants are in clinical use. From the literature review near about 178 medicinal plants are reported to possess a hepatoprotective activity. A drug having beneficial effect on the liver is known as hepatoprotective drug. On the other hand, drugs having toxic effect on the liver are better known as hepatotoxic drugs. The most commonly used parameters to assess the hepatoprotective activity are morphological e.g. Liver weight and volume, biochemical estimations, such as measurement of transaminase activity, SGPT, SCOT, alkaline phosphatase, serum bilirubin, total serum proteins, albumin, globulin and prothrombin time, functional parameters, pentobarbitone and hexobarbitone sleeping time and finally histopathological study regarding presence of necrosis, fatty degeneration and cirrhosis. In this review, we will briefly discuss hepatotoxicity and hepatoprotective agents.</span></p> 2019-09-01T00:00:00+00:00 ##submission.copyrightStatement##