PharmaTutor <p><span style="font-family: verdana,geneva,sans-serif;"><span style="font-family: georgia,serif;">The PharmaTutor&nbsp; <strong>(ISSN: 2347 - 7881)</strong> is a monthly published online journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences &amp; Lifesciences.<br></span></span></p> PharmaTutor Edu Labs en-US PharmaTutor 2347-7881 Muntingia Calabura (Jamaica Cherry): An Overview <p>Muntingia, or Jamaica Cherry, is a small, fast--‐growing tree that can reach up to 40 ft. tall at full maturity. The soft leaves are evergreen and have an alternate phyllotaxy. Leaves are dark green on top and light green underneath. The small, white flowers feature yellow stamens in the center. The small, round fruits are abundant, and depending on the variety, have a red or yellow color. Fruits are edible raw or made into jam. The fruit possessed potent anti-inflammatory activity. The flowers have antiseptic and antispasmodic qualities, and are made into medicinal teas. The M. calabura leaves exhibited potential anti-proliferative and antioxidant activities. The present study on Muntingia is to give an overview on traditional uses and pharmacological activity.</p> S Sarojini B Mounika ##submission.copyrightStatement## 2018-11-01 2018-11-01 6 11 1 9 10.29161/PT.v6.i11.2018.1 Updates on the Amendments Made on the Drugs and Cosmetics Rule 1945 (Amendment Rules 2018) on Labeling of Medicines Rules 96 & 97 <p>Context: To update the amendments made in Gazette Notification for changes in the Manner of Labeling of Medicine as specified in Rule 96 &amp; 97, which shall be required to be displayed on the inner most container and every outer in which the medicines are packed on the basis of Pharmacological Category of the product under which it falls.<br>Objective: To prepare label of the medicines as per the mandatory information to be displayed on the label of the container so that the text matter on the label is clear, readable as shall fulfill the necessary requirements of Drug &amp; cosmetic Act.</p> Shrikant Godiyal Lucky Singh Sonu Panwar ##submission.copyrightStatement## 2018-11-01 2018-11-01 6 11 10 17 10.29161/PT.v6.i11.2018.10 An incisive review of Nanosensors <p>Nanosensors are increasing expanding consideration because of the need to distinguish and measure chemical and physical properties in hard to achieve biological and industrial systems that are in the nano-scale locale. An option is given in the fast improvement of nanosensors which have favorable position to recognize sustenance segments in a simple and brisk way. Different kinds of nanosensors are being produced to meet the diverse necessities in food inspection (nanosensors for identification of outside and interior conditions in food packaging, carbon nanotubes based electrochemical sensors for recognition of cations, anions and organic compounds in nourishment, different aptamers for identification of pesticides, anti-microbials, overwhelming metals, microbial cells and poisons).</p> Inderjeet Kaur Maninder Kaur Navneet Kaur ##submission.copyrightStatement## 2018-11-01 2018-11-01 6 11 18 21 10.29161/PT.v6.i11.2018.18 Some Natural Isolated Compounds as Anticancer Agents <p>Worldwide cancer is the major cause of death. Almost 8.8 million people died due to different types of cancer such as lung cancer, liver cancer, breast cancer, stomach cancer, blood cancer etc. in 2015. Government of various countries and some private organizations are spending trillions dollars for the research in cancer. According to report of WHO treatment cost of cancer is approximately US$ 1.16 trillion per year and this amount is increasing per year. Despite of huge work the exact cause of genesis is still unknown. Couples of therapies like chemotherapy, radiation, surgery and targeted therapy are available with some detrimental effect. Now scientists are seeking lead molecule from naturally occurring substances due to high safety margin as compared to current approaches. Natural phytochemicals are prominent strategy for prevention, treating, and curing cancer. There are many phytochemicals from herbs having potent anticancer property. Generally these phytochemicals treat cancer by different mechanisms like augmenting apoptosis, cell cycle arrest, targeting to some specific cancer inducing proteins, increasing cytotoxicity etc. This is our little attempt to gather information of phytochemicals having anticancer property such as Etoposide, Curcumin, Vincristine, etc. with postulated mechanism. Etoposide is effective in lung cancer, ovarian cancer by inhibiting type II Topoisomerase. Various research revealed that Curcumin is effective in different types of cancers by increasing apoptosis and targeting specific gene such as MDM2 oncogene is inhibited through the ETS2 transcription factor by modulation of signaling pathway PI3K/mTOR in breast cancer. Vincristine shows anticancer property by oncogenic EWS-FLI1 fusion protein inhibition which cause G2-M phase cell cycle arrest &amp; reduce tumor. This review depicts few phytochemicals having anticancer property such as Etoposide, Curcumin, vincristine, etc. with possible mechanism.</p> Nilesh J Patel Rupesh A Mishra Nikunjana A Patel Priyanshi V Barad ##submission.copyrightStatement## 2018-10-31 2018-10-31 6 11 22 29 10.29161/PT.v6.i11.2018.22 Managing Rational Use of Drugs in Bangladesh <p>Despite substantial progress in drug manufacturing, irrational drug use, inappropriate prescribing, inadequate access to essential drugs are major problems affecting the total health care system badly of Bangladesh. Virtually, all the drugs are available without prescriptions and self-medications are highly common. Access to essential medicines is significantly less than that mentioned in the official documents. Price of essential medicines is not consistent and the drugs regulating authority does not have any control over pricing of drugs. In short, the economical development and educational flourishment doesn’t represent the health sector of Bangladesh.</p> AK Mohiuddin ##submission.copyrightStatement## 2018-11-01 2018-11-01 6 11 30 35 10.29161/PT.v6.i11.2018.30 A Review on Analytical Methods for the estimation of Rizatriptan, an Antimigraine Drug <p>Rizatriptan is a selective serotonin receptor agonist of the 1B and 1D sub types used in the acute treatment of migraine attacks. Effective analytical procedures are required for qualitative and quantitative determination of a drug. An extensive literature survey has been conducted in various analytical and pharmaceutical journals and the analytical methods which were developed and used for estimation of Rizatriptan in single or in combination with other drugs in bulk drugs, pharmaceutical formulations, biological fluids, stability indicating and impurity profiling methods have been reviewed. Various analytical methods used for the estimation of Rizatriptan reviewed in this paper includes Ultraviolet spectrometry, Visible spectrometry, High performance thin layer chromatography, High performance liquid chromatography, Liquid chromatography- mass spectrometry</p> Pushpa latha B Sailaja ##submission.copyrightStatement## 2018-11-01 2018-11-01 6 11 36 52 10.29161/PT.v6.i11.2018.36 Gastro Esophageal Reflux Disease <p>Gastro esophageal reflux disease is also known as GERD. It is a long term condition where stomach contents come back up into the esophagus. Resulting in either symptoms or complications. Symptoms include the taste of acid in the back of the mouth, heartburn, bad breath, chest pain, vomiting, breathing problems and wearing away of the teeth complications includes oesophagitis, esophageal strictures and Barrett’s esophagus. Recent studies have demonstrated that peripheral and central factors are pivotal for the emergence of symptoms after gastroesphageal reflux had occurs supporting the view the GERD is a sensory -motor disorder rather than motor disorder alone. The primary pathophysiologic event in GERD is the movement of acid, pepsin and other injurious substance from the stomach in to the esophagus. GERD is a common problem world-wide, the frequency and severity of GERD and severity of GERD and its complications such as burette’s esophagus and geographic variations. most studies from India suggests that these might be less in the Indian population on the other hand studies in a multiethnic population showed that people of Indian origin are at higher risk of GERD than ethnic Malay of Chinese.</p> ZL Qadrie N Mounika T Vijayalaxmi M Nagavamsidhar ##submission.copyrightStatement## 2018-11-01 2018-11-01 6 11 53 59 10.29161/PT.v6.i11.2018.53