PharmaTutor <p><span style="font-family: verdana,geneva,sans-serif;"><span style="font-family: georgia,serif;">The PharmaTutor&nbsp; <strong>(ISSN: 2347 - 7881)</strong> is a monthly published online journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences &amp; Lifesciences.<br></span></span></p> en-US (Dr. Sanjeev Acharya) (Rajesh Vagh) Wed, 01 May 2019 00:00:00 +0000 OJS 60 Receptor Targeting Liposomal Nano Formulations for Drug Delivery in Breast Cancer <p>Recently, incidences of <a href="">breast cancer</a>&nbsp;are increasing and it has become a leading cause of cancer related deaths of women globally. Though pharmaceutical and biotechnology industries are developing, and researchers are working to find a better treatment of breast cancer patients to improve the effectiveness of current therapy, the survival rate is very low. A lot of research is going on based on lipid particulate systems which has versatile applications for the treatment of life-threatening diseases such as breast cancer. Out of various lipid particulate systems, liposomes have been studied and explored widely as they have many applications such as improving solubility of antitumor drugs, reduces the side effects, long circulation in blood, possibility of passive and active targeting to tumor cells. Liposomal system is most popular because of its biocompatibility, capability to encapsulate hydrophilic as well as hydrophobic drugs, ease of surface modification and wide range of applications.&nbsp; &nbsp;Thus, a thorough research is ongoing for upgradation of liposomes as multipotential carriers and its effective therapeutic. Therefore, this review article includes the recent development and techniques of liposomal nano formulations drug delivery system. This review majorly focuses on the breast cancer and its therapy, current challenges in experimental and clinical studies in liposomal formulations. &nbsp;&nbsp;</p> Dr.Jigar Vyas, Juhi H. Patel, Ria Nitinbhai Patel, Kapil Kumar Vinodbhai Daxini ##submission.copyrightStatement## Wed, 01 May 2019 00:00:00 +0000 Scientific Approach to Treat Tobacco Addiction – A review <p>In this current review , we have gathered the information regarding the various aspects of tobacco. The propagation &amp; measures taken like the climatic condition for instance temperature ,soil texture are discussed in this review. The different methods of isolation using fungal pectinase to release mesophilic cells &amp; its further process are reviewed in this work .Attempts have been made to gather information on the side effects of tobacco &amp; the various measures to treat nicotine addiction are highlighted in this article.</p> Shashank N Nayak, Pooja A M, Apsari Anjum, Shwetha Kamath KS ##submission.copyrightStatement## Wed, 01 May 2019 00:00:00 +0000 An Updated overview on Phytochemical Screening and Pharmacological Screening of Borassus Flabellifer Linn <p>Plants plays a major role in health as medicine since the human era began. The Palmyra tree is the official tree of Tamil Nadu state in India. All of its parts could be used for medicinal properties. This magnanimous tree is found with gums, albuminoids, steroidal glycosides, fats, and carbohydrate like sucrose, spirostane type steroids like borassosides and dioscin. The aim of this review was the updated research of this plant for its pharmacological screening. This review article is focused attentively on medicinal property of the plant Borassus flabellifer linn belongs to the family of Arecaceae. In this review was concluded that the plants are having various pharmacological actions like anti-inflammatory, analgesic, anthelmintic, diuretic, anti-diabetic, anti-oxidant, anti-nociceptive, anti-bacterial, wound healing, anti-convulsant, and anti-microbial properties.</p> Saranya K, Sivakumar G, Gopalasatheeskumar K, Arulkumaran G ##submission.copyrightStatement## Wed, 01 May 2019 00:00:00 +0000 Foods Containing Nitrosoamines Causes Carcinogenesis – An Insight Review <p>Nitrosamines belongs to a family of potent carcinogenic substances that have been rigorously stidie dover the past decades due to its extreme carcinogenic nature to animals as well as humans. It is generally found as an industrial contaminant but can also the exposure to the substance maybe due to soil, water or food contamination. The carcinogenicity to humans is caused by the metabolised product of nitrosamines especially, N-nitroso compounds.</p> <p>One of the most extensively studied compound of this is N-Nitroso dimethylamine due to its potency in the formation of cancers. N-Nitroso dimethylamine induces cancers in the stomach due to its metabolism in the gut and the production of toxic metabolites. Frequently N-Nitroso dimethylamine exposure is via skin absorption and also via ingestion.</p> <p>Under extensive researches in mice, in oral administration it is found to induce cancers of lung, kidney and stomach. It was proposed that the toxic nature of N-Nitroso dimethylamine is due to the highly – oxygen reactive species forming metabolite nature and also altering the activity of liver microsomal enzymes.</p> Sai Kushal Gunturu, Tulasi Ram Nayak Menavath, Ramadoss Karthikeyan ##submission.copyrightStatement## Wed, 01 May 2019 00:00:00 +0000 An Overview of Ebola Virus - It's Pathogenesis, Treatment and Vaccination <p>Ebola virus disease (EVD) is previously known as Ebola hemorrhagic fever. It is a serious fatal illness to human. EVD is caused by the Ebola virus. The outbreak of Ebola virus began in the Republic of Guinea in February 2014.The 2014 West Africa outbreak is believed to be most severely recorded in medical history. Around 1440 cases with 826 deaths have been reported. But around 16,000 people survived in West Africa. A cellular protein acts as a receptor for Ebola virus and Marburg virus. TIM-1 acts as a receptor for Ebola virus which is a cellular protein. It is transmittable disease which occurs by the contact with the blood or body fluids of a person who was infected or died from EVD, contaminated objects like needles and infected animals or meat. Burial ceremonies in which mourners have direct contact with the body of the deceased person can also major role in transmission of Ebola. EVD has an incubation period of about 2 to 21 days, and the infection has an acute onset without any carrier status. At present, there is no particular type of treatment for EVD, so it is important to avoid infection exceeded 80%, modern medicine in public health measures have been taken to reduce the smack of EBD on individuals and communities. Treatment for Ebola virus involves early, truculent, supportive care with rehydration. Typical symptoms of Ebola virus disease include fever, diarrhea, nausea and vomiting for about 3-5 days and may lasts up to one week, abdominal pain. Upon increase in severity of the virus the patient may suffer from confusion, dehydration, and hypotension. These conditions eventually may lead to death. Ebola virus may be spread due to insufficient medical facilities, poor sanitation, unsafe burial practices. Ebola virus does not replicate through cell division. There is no definitive cure and management is mainly supportive ensuring adequate hydration and symptomatic treatment.</p> Naga Subrahmanyeswari, Srinivasa Babu, Gajula Supriya, Bandi Srilekha ##submission.copyrightStatement## Wed, 01 May 2019 00:00:00 +0000