Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Amlodipine Besylate and Candesartan Cilexetil in Synthetic Mixture
Keywords:
Amlodipine besylate, Candesartan cilexetil, Q-Absorbance ratio spectrophotometric method, UV spectroscopy
Abstract
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical q-absorbance method for the simultaneous determination of Amlodipine besylate and Candesartan cilexetil in synthetic mixture. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an Isoabsorptive point at 242 nm in Methanol. The second wavelength is used 255 nm, which is λmax of Candesartan cilexetil in Methanol. The linearity was obtained in the concentration range of 5-25 μg/mlof both drugs. The concentration of drugs was determined by using ratio of absorbance at isoabsorptive point and at the λ-max of Candesartan cilexetil. The method was successfully applied to pharmaceutical dosage form because of no interference. The result of analysis has been validated by recovery studies.
References
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19) USP32, NF27 VOL.I (1225) Validation of compendial procedure, 2009, pp 733-736 & 1872 -1873.
20) Sureshkumar GV, Rajendraprasad Y. “Development and validation of reversed phase HPLC method for telmisartan and amlodipinein tablet dosage form”. International Journal of Pharmaceutical Science, 2010, 2(3), 128-31.
21) Shah PN, Patel BN, Patel CN and Dave JB, “RP-HPLC Method of Simultaneous Estimation of Enalapril maleate and Lercanidipine HCl in synthetic mixture”, International Journal of Research in Pharmacy and Chemistry, 2011, 1(3), 308-314.
22) Vyas AJ, Patel JK, Bhandari A, Chavda JR and Sheth NR, “Simultaneous Estimation of Lornoxicam and Paracetmaol by Vierodt’s Method in API and in Synthetic mixture”, International Journal of ChemTech Research, 2011 3(3), 1269-1273.
23) Patil BK, RaghevendraNG,Jadhav KD, KulkarniupendraCV, Gada MJ,”Estimation of candesartan cilexetil in bulk and tablet dosage form by u.v spectrephotometric method”,International journal of research in ayrveda & pharmacy, 2011, 2(1), 204-206.
24) General monographs of hypertensive drugs, “Japanese Pharmacopoeia”,by Ministry of Health, Labour & Welfare Ministerial Notification No.519,14th Edition,Part II, (JP) , for candesartan cilexetil: 2376-2378, & for Amlodipine besylate: 2363-2365, 2011.
25) Mathrusri AS, Rav NB, Kushwala FB, “Liquid chromatography method for simultaneous quantitative determination of candesartan cilexetil and hydrochlorthiazide in pharmaceutical dosage form”.Journal of drug delivery & therapeutics, 2012, 2(2), 48.
26) Kalyani GK, Deshmukh BN, Vaishanv YTand Kashyap PF,”, Anlytical method development and validation for the estimation of candesartan by derivative spectroscopy (First order and second order ).”International journal of pharmaceutical science and research, 2012, 3(5), 1379-1384.
27) Drug Bank Open drug and open target database :
i. drugbank.ca/drugs/DB00381 (Amlodipine)
ii. drugbank.ca/drugs/DB00796 (Candesartan)
28) For Marketed preparation : MIMS.com/mimsphillipines
2) Chatwal GR, Anands, Ultraviolet-Spectroscopy, Instrumental Methods of Chemical Analysis, Mubai, Himalaya Publishing House, 2000.
3) Sweetman SC. Martindale: The complete drug refference, pharmaceutical press, 33rd edn. ALondon: The pharmaceutical press, 2002, 862 & 907.
4) Govi-verlag, “Application of 1st derivative spectrophotometry for simultaneous estimation of candesaran cilexetil and hydrochlorthiazide”, Die pharmazie-An international journal of pharmaceutical science, 2003, 58(11), 796-800.
5) Backett AH, and Stenlake JB, Practical Pharmaceutical Chemistry, First Edition, Reprint, CBS Publishers and Distributors, New Delhi, 2004, 275 – 325.
6) International Conference on Harmonization of Technical Requirments for Registration of Pharmaceutical for Humanuse. Validation of analytical proceure: Text book and Methodology ICH Q2 (R1), 2005.
7) Miller JM, Chromatography, Concept And Contract, 2nd Edn, John Willey And Sons, Newyork, 2005, 43-45.
8) Sharma S, Sher P, Badve S, Atmaram PP. Recent advances in Spectroscopic technique, 6th Edn, London, APS Publisher and distributors, 2005, E 618-E 625.
9) Kanakapura B, Umakanthappa C, and Paregowda N, “Spectrophotometric and High Performance Liquid Chromatographic Determination of Amlodipine Besylate (ADB) in Pharmaceuticals”, ScienceAsia, 2005, 31(2), 13-21.
10) Malesuik MD, Cardos SG, Bajerski L, Lanzanova FA, “Determination of amlodipine in pharmaceutical dosage forms by liquid chromatography and ultraviolet spectrophotometry.”, Journal of AOAC international, 2006, 89(2), 359-364.
11) The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, Merck & Co, Inc, Whitehouse Station, NJ, 2006, 497 & 281.
12) Rang HP, Dale MM, and Ritter JM, Pharmacology, 6th Edn, Churchill Livingstone, New York, 2007, 294-315.
13) Mendham J, Denny JD, Barner & Thomas MJK, Vogel’s Text book of Quantitative Chemical Analysis, 6th Edn, Dorling Kindersley, India, 2007, 717-756.
14) “Indian Pharmacopoeia ”, Volume 2, Ghaziabad: Govt. of India Ministry of Health & Family welfare, The Controller of Publication, 2007, 714-716, 749-752, A-84.
15) “British Pharmacopoeia”, Vol-I, London: HMSO Publication, 2007, 137-138.
16) Tripathi KD, Essential of Medical Pharmacology, 6th Edn, Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, 2008, 540,522.
17) Garg G, Saraf S, Saraf S, Development and validation of “Amlodipine Besylate and Enalepril Maleate in combined dosage form”, Trends in Applied sciences research, 2008, 3(3), 278-284.
18) Kakde RB, Kotak VH, Barsagade AG, Chaudhary NK, and Kale DL, “Spectrophotometric Method for Simultaneous Estimation of Amlodipine Besylate and Bisoprolol Fumarate in Pharmaceutical Preparation”, Research Journal of Pharamaceuticals and Technolgy, 2008, 1(4), 513-515.
19) USP32, NF27 VOL.I (1225) Validation of compendial procedure, 2009, pp 733-736 & 1872 -1873.
20) Sureshkumar GV, Rajendraprasad Y. “Development and validation of reversed phase HPLC method for telmisartan and amlodipinein tablet dosage form”. International Journal of Pharmaceutical Science, 2010, 2(3), 128-31.
21) Shah PN, Patel BN, Patel CN and Dave JB, “RP-HPLC Method of Simultaneous Estimation of Enalapril maleate and Lercanidipine HCl in synthetic mixture”, International Journal of Research in Pharmacy and Chemistry, 2011, 1(3), 308-314.
22) Vyas AJ, Patel JK, Bhandari A, Chavda JR and Sheth NR, “Simultaneous Estimation of Lornoxicam and Paracetmaol by Vierodt’s Method in API and in Synthetic mixture”, International Journal of ChemTech Research, 2011 3(3), 1269-1273.
23) Patil BK, RaghevendraNG,Jadhav KD, KulkarniupendraCV, Gada MJ,”Estimation of candesartan cilexetil in bulk and tablet dosage form by u.v spectrephotometric method”,International journal of research in ayrveda & pharmacy, 2011, 2(1), 204-206.
24) General monographs of hypertensive drugs, “Japanese Pharmacopoeia”,by Ministry of Health, Labour & Welfare Ministerial Notification No.519,14th Edition,Part II, (JP) , for candesartan cilexetil: 2376-2378, & for Amlodipine besylate: 2363-2365, 2011.
25) Mathrusri AS, Rav NB, Kushwala FB, “Liquid chromatography method for simultaneous quantitative determination of candesartan cilexetil and hydrochlorthiazide in pharmaceutical dosage form”.Journal of drug delivery & therapeutics, 2012, 2(2), 48.
26) Kalyani GK, Deshmukh BN, Vaishanv YTand Kashyap PF,”, Anlytical method development and validation for the estimation of candesartan by derivative spectroscopy (First order and second order ).”International journal of pharmaceutical science and research, 2012, 3(5), 1379-1384.
27) Drug Bank Open drug and open target database :
i. drugbank.ca/drugs/DB00381 (Amlodipine)
ii. drugbank.ca/drugs/DB00796 (Candesartan)
28) For Marketed preparation : MIMS.com/mimsphillipines
Published
2014-05-01
How to Cite
[1]
B, K., Zala, P. and S, F. 2014. Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Amlodipine Besylate and Candesartan Cilexetil in Synthetic Mixture. PharmaTutor. 2, 5 (May 2014), 167-178.
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Articles
