Formulation and Evaluation of Fast Dissolving Tablet of Silymarin

Abstract

In this investigation mouth dissolving tablets of Silymarin were prepared using different superdisintegrants by dry granulation method. Fast dissolving tablets were evaluated for physicochemical properties and in vitro dissolution. The preformulation studies and tablet evaluation test were performed and result were within the limit. The powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner ratio. The powder blend show satisfactory flow properties. The silymarin tablet evaluated for tablet general appearance, hardness test, weight variation and drug content estimation. Oral route is the most preferred route for administration of various drugs because it is regarded as safest most convenient and economical route. Recently researcher develop the new dosage form fast dissolving tablet (FDT) with improve patient compliance and convenience. Fast dissolving tablets which dissolve rapidly in saliva without additional water and chewing. Fast dissolving tablets overcome the disadvantages of conventional dosage form especially dysphagia in pediatric and geriatric patients.
All the formulations shows uniform weight, hardness and friability data indicates good mechanical resistance of the tablet. All the tablets were disintegrated between min. The optimized (F6) formulation showed good disintegration time and release profile with maximum drug being released.