Toxicological Screening of Gowri Chinthamani Chendooram - A Siddha Metallic Preparation

Abstract

Gowri chinthamani chendooram, a siddha drug was evaluated for its acute and chronic toxicity studies in wistar albino rats with reference to haematological, bio-chemical and histopathological studies. Acute study revealed a maximum tolerated does of 640 mg/100 gm b.w chronic toxicity study revealed a minimum toxic effect at adoes level of 40 mg/100 gm b.w. Where in, the changes observed were non-specific. The toxicity findings were dose specific, which had tissue damage in higher dosages.