Targeted Drug Delivery Systems for Lung Cancer
Keywords:
Targeted Drug Delivery Systems, Lung Cancer, Nanocarrier
Abstract
In the present scenario, lung cancer is one of the most prevalent and malignant cancer especially among the smoking group of people. The targeted delivery of chemotherapeutic agents to the lungs represents a novel therapeutic approach in lung cancer. Lung is an ideal route for administration of anticancer drug as it provides larger alveolar surface area, low thickness of epithelial barrier & extensive vascularization. Nanoparticles with nanocarriers have possibility of cell-targeted drug delivery with minimal systemic side effect and toxicity. Pulmonary epithelial cell, enzymes, receptors and genes are the target of the targeted drug delivery in lung cancer. This paper reviews the till date targeted drug delivery research performed for the treatment of lung cancer.
References
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2. Katzel JA, Fanucchi MP, Li Z. Recent advances of novel targeted therapy in non-small cell lung cancer. J HematolOncol. 2009; 2: 2.
3. Babu A, Templeton AK, Munshi A, Ramesh R. Nanoparticle-Based Drug Delivery for Therapy of Lung Cancer: Progress and Challenges. Journal of Nanomaterials Volume 2013, Article ID 863951, 11 pages.
4. Hirokawa K. International symposium on airway diseases: Etiology to clinic. 2012
5. Roa WH, Azarmi S, Al-Hallak MH, Finlay WH, Magliocco AM, Lobenberg R, et al. Inhalable nanoparticles, a non-invasive approach to treat lung cancer in a mouse model. J Control Release.2011;150: 49–55.
6. Pilcer G, Amighi K. Formulation strategy and use of excipients in pulmonary drug delivery. Int J Pharm. 2010; 392:1–19.
7. Goel A, Baboota S, Sahni JK, Ali J. Exploring targeted pulmonary delivery for treatment of lung cancer. Int J Pharm Investig. 2013 Jan-Mar; 3(1): 8–14.
8. Sung JC, Pulliam BL, Edwards DA. Nanoparticles for drug delivery to the lungs. Trends Biotech. 2007; 25: 563–70.
9. Azarmi S, Roa WH, Lobenberg R. Targeted delivery of nanoparticles for the treatment of lung diseases. Adv Drug Deliv Rev. 2008; 60: 863–75.
10. Anabousi S, Bakowsky U, Schneider M, Huwer H, Lehr CM, Ehrhardt C. In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer. EurJPharm Sci. 2006; 29: 367–74.
11. Videira M, Almeida AJ, Fabra A. Preclinical evaluation of a pulmonary delivered paclitaxel-loaded lipid nanocarrier antitumor effect. Nanomed. 2012 Oct; 8(7): 1208-15.
12. Peng XH, Wang Y, Huang D, Wang Y, Shin HJ, Chen Z, Spewak MB, Mao H, Wang X, Chen Z,Nie S, and Shin DM. Targeted Delivery of Cisplatin to Lung Cancer Using ScFvEGFR-Heparin-Cisplatin Nanoparticles. ACS Nano. 2011 December 27; 5(12): 9480–9493.
13. Hureaux J, Lagarce F, Gagnadoux F, Vecellio L, Clavreul A, Roger E, Kempf M, Racineux JL, Diot P, Benoit JP, Urban T. Lipid nanocapsules: ready-to-use nanovectors for the aerosol delivery of paclitaxel. Eur J Pharm Biopharm. 2009 Oct; 73(2): 239-46.
14. Hitzman CJ, Wattenberg LW, Wiedmann TS. Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles. J Pharm Sci. 2006; 95: 1196–11.
15. Patlolla RR, Chougule M, Patel AR, Jackson T, Tata PN, Singh M. Formulation, characterization and pulmonary deposition of nebulizedcelecoxib encapsulated nanostructured lipid carriers. J ControlRelease. 2010; 144: 233–41.
16. Liu Z, Wang Y, Zhang N. Micelle-like nanoassemblies based on polymer-drug conjugates as an emerging platform for drug delivery. ExpertOpin Drug Deliv. 2012; 9(7): 805–822.
17. Verma NK, Staunton KC, Satti A, Gallagher S, Ryan KB, Doody T, McAtamney C, MacLoughlin R, GalvinP, Burke CS, Volkov Y, and Gun’ko YK. Magnetic core-shell nanoparticles for drug delivery by nebulisation. J Nanobiotechnology. 2013; 11: 1.
18. Vyas SP, Khar RK. Liposomes. In: Vyas SP, Khar RK, editors. Targeted and Controlled Drug Delivery: Novel Carrier Systems. New Delhi: CBS Publishers; 2002; 173–43.
19. Boulikas T. Low toxicity and anticancer activity of a novel liposomal cisplatin (Lipoplatin) in mouse xenografts. OncologyReports, 2004; 12(1): 3–12,.
20. Tseng CL, Wang TW, Dong GC. Yueh-Hsiu Wu S, Young TH, Shieh MJ, Lou PJ, Lin FH.. Development of gelatin nanoparticles with biotinylated EGF conjugation for lung cancer targeting. Biomaterials, 2007; 28(27): 3996–4005.
21. Jiang L, Li X, Liu L, and Zhang Q. ThiolatedchitosanmodifiedPLA-PCL-TPGS nanoparticles for oral chemotherapyof lung cancer. Nanoscale Research Letters, 2013; 8(1): 66.
22. Conde J, Doria G, and Baptista P. Noble metal nanoparticles applications in cancer. Journal of Drug Delivery, vol. 2012, Article ID 751075, 12 pages, 2012.
23. Peng G, Tisch U, Adams O, Hakim M, Shehada N, Broza YY, Billan S, Abdah-Bortnyak R, Kuten A, Haick H. Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nature Nanotechnology. 2009; 4(10): 669–673.
24. Galimberti F, Thompson SL, Liu X, Li H, Memoli V, Green SR, DiRenzo J, Greninger P, Sharma SV, Settleman J, Compton DA, and Dmitrovsky E. Targeting the Cyclin E-Cdk-2 Complex Represses Lung Cancer Growth by Triggering Anaphase Catastrophe. Clin Cancer Res. 2010; 16(1): 109–120.
25. Kiran C, Deepika P. Lung Cancer: MicroRNA and Target Database. Retraction in: ZhongguoFei Ai ZaZhi, 2012, 15(8):470.
26. Data retrieved from US National Institutes of Health website (http://clinicaltrials.gov/) on August 21, 2013.
Published
2015-02-01
How to Cite
[1]
Waheed, A., Gupta, A. and Patel, P. 2015. Targeted Drug Delivery Systems for Lung Cancer. PharmaTutor. 3, 2 (Feb. 2015), 38-42.
Section
Articles
