Dissolution Method Devolopment of Fluconazole in Fluconazole Tablets Dossage Form
Keywords:
Ebola haemorrhagic fever, EBOV, WHO, NHP, EVD
Abstract
The present research work discusses the development of a dissolution method for Fluconazole using UV spectrophotometer. Simple, accurate and cost efficient dissolution method has been developed for the estimation of Fluconazole in bulk and tablet dosage form. The optimum conditions for the dissolution of the drug were established. The dissolution media was found to be 0.1N HCl (pH 1.2). The apparatus was found to be USP II, Paddle and the speed was found to be 50 rpm for 30 minutes time interval.
References
1. drugbank.ca/drugs/DB00196
2. Klavs F, Analytical profiles of Drug and Excipients (Academic Press, An Imprint of Elsevier, New Jersey), 27(1987) 67-112.
3. Martidale, The Extra Pharmacopoeia, edited by JEF Renolds (Royal Pharmaceutical Soc.,London), 1990, 404- 406.
4. Hillis J, Morelli I, Neville D, Fox J and Leary A C, Chromatogr, 67 (11/12) 2008, 995-998.
5. CDER Guidance for Industry, “Waiver of In vivo Bioavailability and Bioequivalence studies for Immediate- Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System”.
6. USP General chapter <1092> The dissolution procedure : Development and validation.
7. USP General Chapter <711> Dissolution.
2. Klavs F, Analytical profiles of Drug and Excipients (Academic Press, An Imprint of Elsevier, New Jersey), 27(1987) 67-112.
3. Martidale, The Extra Pharmacopoeia, edited by JEF Renolds (Royal Pharmaceutical Soc.,London), 1990, 404- 406.
4. Hillis J, Morelli I, Neville D, Fox J and Leary A C, Chromatogr, 67 (11/12) 2008, 995-998.
5. CDER Guidance for Industry, “Waiver of In vivo Bioavailability and Bioequivalence studies for Immediate- Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System”.
6. USP General chapter <1092> The dissolution procedure : Development and validation.
7. USP General Chapter <711> Dissolution.
Published
2015-05-01
How to Cite
[1]
D, A., L, J. and V, G. 2015. Dissolution Method Devolopment of Fluconazole in Fluconazole Tablets Dossage Form. PharmaTutor. 3, 5 (May 2015), 29-35.
Section
Articles
