Activity of chalcone and its derivatives - a Review
Keywords:
Chalcone, flavonoids, isoflavonoids, pharmacological
Abstract
Chalcones considered as the precursor of flavonoids and isoflavonoids abundantly found in plants, and have also been shown to display a diverse array of pharmacological activities. This review is complementary to earlier reviews and covers more recent report of antimicrobial activity of chalcones as well as its important role as an intermediate for the synthesis of different synthetic molecules. The enone linkage presents in basic structure play crucial role for the activity of chalcone and chalcone derivatives. The members of the chalcone and flavonoid family have attracted a great deal of interest due to it has showed diffent activity as antibacterial, antifungal, anti-inflammatory, antihyperglycemic anti HIV and anticancer pharmacological activity. Recently a molecule of chalcone has been reported as a novel class of HIV-1 integrase inhibitors. The purpose of this review is to focus on some important pharmacological activity of the chalcone and its derivatives.
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2. Zdzislawa Nowakowska. European Jornal of Medicinal Chemistry. 2007, 42,125-137.
3. Carlos Javier Durán-Valle, Isabel M. Fonseca, Vanesa Calvino-Casilda, Maria Picallo, António José López-Peinado and Rosa Maria Martín-Aranda. Catalysis Today, 2005, 107-108, 500-506 .
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5. Daniela Millan , Moises Dominguez ,Marcos Caroli Rezende, , Dyes and Pigments, 2008, 77 441-445.
6. TRINTH THI THUY, ANDREA PORZEL, HELMUT RIPPERGER, TRAN VAN SUNG, GUNTER ADAM, 1998, PII: S30031-9422000411-7.
7. Ram Vishnu J., Saxena Abhishek S. ,Srivastava Shalini, Chandra Subhash, Bioorganic and medicinal Chemistry letters 10, 2010, 2159-2161
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24. Lim, S.S., Kim, H.S., Lee, D.U. Bulletin of the Korean Chemical Society, 2007, 28, 2495-2497.
25. Achanta, G., Modzelewska, A., Feng, L., Khan, S.R., Huang, P., Molecular Pharmacology, 2006, 70426-433.
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33. Zhang Y., Srinivasan B., Xing C., Lü J.,Anticancer Res. 2012 Sep;32(9):3689-98.
34. de Vasconcelos A., Campos V.F., Nedel F., Seixas F.K., Dellagostin O.A., Smith K.R., de Pereira C.M., Stefanello F.M.,Collares T., Barschak A.G., Cell Biochem Funct. 2012 Sep 18
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36. Utsintong M., Massarotti A., Caldarelli A., Theeramunkong S., Med Chem. 2012 Aug 29.
37. Liu Y., Gao X., Deeb D., Arbab A.S., Dulchavsky S.A., Gautam S.C. J Exp Ther Oncol. 2012; 10(1):1-8.
38. Sharma V., Kumar V., Kumar P., Med Chem. 2012, Jun 18
39. Zhang H., Liu J.J., Sun J., Yang X.H., Zhao T.T., Lu X., Gong H.B., Zhu H.L.,Bioorg Med Chem. 2012 May 15;20(10):3212-8.
40. Dong J, Zhang M, Lu L, Sun L, Xu M., Food Chem. 2012 Dec 1;135(3):1220-5
41. Pan Y, Chen Y, Yu X, Wang J, Zhang L, He Y, Zheng Y, Zheng J. ,Cell Physiol Biochem. 2012; 29(5-6):949-58.
Published
2014-01-01
How to Cite
[1]
Sahu, U., Panda, N., B.V.V, R. and Kumar, A. 2014. Activity of chalcone and its derivatives - a Review. PharmaTutor. 2, 1 (Jan. 2014), 62-75.
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