A Review on Acridone Derivatives and its Importance
Keywords:
Acridone, Medicinal Importance
Abstract
Acridoneis an organic compound containing a carbonyl group attached to the 9 position. It may be synthesized by the self-condensation of N-phenylanthranilic acidAcridone and its derivatives can be synthesized by a number of methods such as Ullmann condensation, by benzyne mechanism, by radical reaction of quinines etc. acridone nucleus due to its variety of pharmacological activities. These pharmacological activities include anticancer, antimicrobial, antiviral, antimalarial and anti-inflammatory activities. This review article literature survey summerizes the synthesis and pharmacological activities of acridone and its derivatives.
References
1. C. F. H. Allen and G. H. W. McKee. "Acridone". Organic Syntheses, Coll. 1943; Vol. 2, p.1 (1943); Vol. 19, p.1 (1939).
2. Hisashi Fujioka, Yukihiro Nishiyama, Hiroshi Furukawa, And Nobuo Kumada. "In Vitro and In Vivo Activities of Atalaphillinine and Related Acridone Alkaloids against Rodent Malaria". Antimicrobial Agents and Chemotherapy, 1989; 33(1): 6–9.
3. F.G. Mann; B. C. Saunders. Practical Organic Chemistry. A New Impression Publication. 2007; 4th ed.; p. 217.
4. Stankiewicz-Drogo- A, Dorner B, Erker T, Boguszewska-Chachulska AM .Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication, J Med Chem. 2010; 22; 53(8); 3117-26.
5. Jumat Salimon , Nadia Salih, Emad Yousif, Ayad Hameed, Ayad Kreem Synthesis and pharmacological evaluation of 9(10H)-acridone bearing 1,3,4-oxadiazole derivatives as antimicrobial agents, Arabian Journal of Chemistry, 2010; 3(4); 205–210.
6. Claudia S Sepúlveda, Mirta L Fascio, María B Mazzucco, Maite L Docampo Palacios, Rolando F Pellón, Cybele C García, Norma B D’Accorso and Elsa B Damonte, Synthesis and evaluation of N substituted acridones as antiviral agents against haemorrhagic fever viruses, Antiviral Chemistry & Chemotherapy, 2008; 19:41–47.
7. Chao Huang, Sheng-Jiao Yan, Xiang-Hui Zeng, Bo Sun, Min-Bo Lan and Jun Lin , Synthesis and evaluation of the antitumor activity of polyhalo acridone derivatives , RSC Adv., 2015; 5, 17444-17450.
8. Belmont P, Bosson J, Godet T, Tiano M, Acridine and acridone derivatives, anticancer properties and synthetic methods: where are we now? Anticancer Agents Med Chem. 2007 Mar; 7(2); 139-69.
9. Grzegorz Cholewinski, Krystyna Dzierzbicka, Aleksander M. Kodziejczyk, Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis, pharmalogical reports, 2011; 63(3); 305-336.
10. Ryo Nishio, Stephane Wessely, Masaharu Sugiura, and Sh- Kobayashi, Synthesis of Acridone Derivatives Using Polymer-Supported Palladium and Scandium Catalysts, J. Comb. Chem., 2006; 8 (4); 459–461.
11. Stankiewicz-Drogo- Anna, Dorner Bernd, Erker Thomas, Boguszewska-Chachulska Anna M, Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication, Journal of medicinal chemistry, 2010; 53(8); 3117-26
2. Hisashi Fujioka, Yukihiro Nishiyama, Hiroshi Furukawa, And Nobuo Kumada. "In Vitro and In Vivo Activities of Atalaphillinine and Related Acridone Alkaloids against Rodent Malaria". Antimicrobial Agents and Chemotherapy, 1989; 33(1): 6–9.
3. F.G. Mann; B. C. Saunders. Practical Organic Chemistry. A New Impression Publication. 2007; 4th ed.; p. 217.
4. Stankiewicz-Drogo- A, Dorner B, Erker T, Boguszewska-Chachulska AM .Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication, J Med Chem. 2010; 22; 53(8); 3117-26.
5. Jumat Salimon , Nadia Salih, Emad Yousif, Ayad Hameed, Ayad Kreem Synthesis and pharmacological evaluation of 9(10H)-acridone bearing 1,3,4-oxadiazole derivatives as antimicrobial agents, Arabian Journal of Chemistry, 2010; 3(4); 205–210.
6. Claudia S Sepúlveda, Mirta L Fascio, María B Mazzucco, Maite L Docampo Palacios, Rolando F Pellón, Cybele C García, Norma B D’Accorso and Elsa B Damonte, Synthesis and evaluation of N substituted acridones as antiviral agents against haemorrhagic fever viruses, Antiviral Chemistry & Chemotherapy, 2008; 19:41–47.
7. Chao Huang, Sheng-Jiao Yan, Xiang-Hui Zeng, Bo Sun, Min-Bo Lan and Jun Lin , Synthesis and evaluation of the antitumor activity of polyhalo acridone derivatives , RSC Adv., 2015; 5, 17444-17450.
8. Belmont P, Bosson J, Godet T, Tiano M, Acridine and acridone derivatives, anticancer properties and synthetic methods: where are we now? Anticancer Agents Med Chem. 2007 Mar; 7(2); 139-69.
9. Grzegorz Cholewinski, Krystyna Dzierzbicka, Aleksander M. Kodziejczyk, Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis, pharmalogical reports, 2011; 63(3); 305-336.
10. Ryo Nishio, Stephane Wessely, Masaharu Sugiura, and Sh- Kobayashi, Synthesis of Acridone Derivatives Using Polymer-Supported Palladium and Scandium Catalysts, J. Comb. Chem., 2006; 8 (4); 459–461.
11. Stankiewicz-Drogo- Anna, Dorner Bernd, Erker Thomas, Boguszewska-Chachulska Anna M, Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication, Journal of medicinal chemistry, 2010; 53(8); 3117-26
Published
2015-10-01
How to Cite
[1]
Yerragunta, V., Reddy, E., Kishore, M., rao, H.O., Sadia, A., Saba, A. and Fatima, S. 2015. A Review on Acridone Derivatives and its Importance. PharmaTutor. 3, 10 (Oct. 2015), 27-29.
Section
Articles
