Activities of aqueous extracts of Mangifera Indica on Parasitaemia level and blood profile of Plasmodium Berghei - infected Albino Mice
Abstract
This study was carried out to assess the effect of Mangifera indica on the percentage parasitaemia and some blood parameters of Plasmodium - infected Albino mice. Forty-two male albino mice, weighing between 20 and 25 g, were used for this research. The mice were randomly assigned into six groups A, B, C, D, E and F of seven mice each. Group A was the negative control, group B was positive control. Mice in groups C, D and E were orally administered with Mangifera indica extract (50 mg/kg, 100 mg/kg and 150 mg/kg body weight) respectively for 5 days starting from the 4th day of inoculation while mice in group F were orally administered with Artesunate for 5 days (3 mg/kg b.w on the first day and 1.5 mg/kg b.w for the next 4 days) starting from the 4th day of inoculation. Blood smears were taken every 2 days to check the parasitaemia level for 14-day post-treatment withdrawal period. The extract has a dose dependent reducing effect on the level of parasitaemia. It also showed that the increase in the rate of reticulocytosis and consequent increase in the number of red blood cells in a dose dependent manner.
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