Protective effect of Ziziphus Jujuba in Lead induced Cerebral Ischemia Reperfusion Injury in Albino Rats

Abstract

Protective effect of ziziphus jujuba in cerebral ischemia reperfusion injury in albino rats. The main aim of the present work is to evaluate the Protective effect of Ziziphus jujuba in cerebral ischemia reperfusion injury in albino rats. Objectives are to test the Preliminary phytochemical screening of Aqueous & Petroleum ether extracts of “ Ziziphus Jujuba”. Group 1: Control group; Group 2: Animals treated with lead 0.1 ml/100 g body weight i.p; Group 3: Animals treated with Petroleum ether extract of Ziziphus Jujuba 250mg/kg; Group 4 : Animals treated with Petroleum ether extract of Ziziphus Jujuba 500mg/kg. All the groups were subjected to pre-treatment for a period of 7 days except Control group to compare the changes in Quantification of infract size in normal and treated groups and to compare the changes in SGOT levels in Control and treated groups. The protective effect of the aqueous extract, petroleum ether extract of Ziziphus Jujuba may be due to the presence of flavonoids, saponins, triterpenoids and tannins. There was a dose dependent increase in cerebral protection in terms of reduction of infarct size of brain tissue and SGOT levels in serum. Furthermore investigation is needed to find out the particular constituent which is responsible this protective activity.