Structure based Antibacterial Activity Of 1,3-Diaryl-2-Propen-1-Ones And Their Recent Pharmacological Interests

Abstract

Chemically chalcones are 1,3–diphenyl-2-propene-1-one, containing dual aromatic rings which are linked to each other via carbon bridge system enveloping keto-ethylenic core structure. Owing to the presence of conjugated double bond and electron dense aromatic ring system, the molecule possesses less redox potential; thus greater probability for characteristic electron transfer reactions. Naturally, conjugated systems of these types are abundantly present in edible plants and are considered to be precursors of bioactive flavonoids and bioflavonoids. Chalcones and their derivatives find numerous industrial applications such as artificial sweeteners, scintillator, polymerization catalyst, fluorescent whitening agent, organic brightening agent, stabilizer against heat, visible light, and ultraviolet radiation.  As a chemo-identifying agent, chalcones have been found useful in elucidating structure of natural products like hemlock, tannin, cyanomaclurin, ploretin, eriodictyol and homoeriodictyol, and naringenin. Pharmacologically, the same molecule acts as a versatile and universally accepted moiety for design and development of numerous bioactive synthetic analogues in search of ideal medicine to conquer human pathological conditions.  The present paper thus designs to explore and study various prospective of chalcones and their derivatives in terms of recent developments and pharmacological importance.