Solid Dispersion- A Review

  • Bhumika Kumar Delhi pharmaceutical sciences and research university
Keywords: solid dispersion, bioavailability, aqueous solubility, carrier, lyophilisation

Abstract

Solid dispersion is an effective way of improving the dissolution rate of poorly water soluble drugs and hence its bioavailability. The water soluble carriers used in preparation of solid dispersion enhance the dissolution rate of the poorly water soluble drug. The review article focuses on the methods of preparation, advantages, disadvantages and characterization of the solid dispersions.

Author Biography

Bhumika Kumar, Delhi pharmaceutical sciences and research university

Department of pharmaceutics,
Delhi pharmaceutical sciences and research university,
New Delhi, India

References

1. Sekiguchi K., Obi.N; Studies on absorption of eutectic mixtures: A comparison of the behaviour of eutectic mixtures of sulphathiazole and that of ordinary sulphathiazole in man; Chem. Pharm. Bull; 1961; 9; 866–872
2. Singh et al; A review on solid dispersion; IJPLS; 2011; 2(9); 1078-1095
3. Dixit AK., Singh RP; solid dispersion – A strategy for improving the solubility of poorly soluble drugs; IJRPBS; 2012; 3(2); 960-966
4. Huda N.H., Saffoon N., Sutradhar K.B., Uddin R; Enhancement of Oral Bioavailability and Solid Dispersion: A Review; Journal of Applied Pharm Sci; 2011; 1; 13-20.
5. Jain C.P., Sharma A; Solid dispersion: A promising technique to enhance solubility of poorly water soluble drug; Int. J of Drug Delivery; 2011; 3; 149-170.
6. Das S.K., Roy S., Kalimuthu Y., Khanam J., Nanda A; Solid Dispersions: An Approach to Enhance the Bioavailability of Poorly Water-Soluble Drugs; Int. J of Pharmacology and Pharmaceutical Technology; 1; 37 – 46.
7. praveen kumar; solid dispersion – A review; Journal of pharmaceutical and scientific innovation; 2012; 1(3); 27-34
8. Jaskirat et al; solubility enhancement by solid dispersion method: A review; Jornal of drug delivery & therapeutics; 2013; 3(5); 148-155
9. Nikghalb et al; Solid Dispersion: Methods and Polymers to increase the solubility of poorly soluble drugs; Journal of Applied Pharmaceutical Science; 2012; 2(10); 170-175
10. Kalia et al; solid dispersion- an approach towards enhancing dissolution rate; Int. J Pharm Sci; 2011; 3(4); 9-19
11. Dixit et al; A review- solid dispersion,2014; World Journal of Pharmacy and Pharmaceutical Sciences; 3(9); 238-257
12. Thakur et al; A review on solid dispersion; World Journal of Pharmacy and Pharmaceutical Sciences; 2014; 3(9); 173-187
Published
2017-02-01
How to Cite
[1]
Kumar, B. 2017. Solid Dispersion- A Review. PharmaTutor. 5, 2 (Feb. 2017), 24-29.
Section
Articles