Preparation and In-Vitro evaluation of Diclofenac Sodium Transdermal Patches
Keywords:
Transdermal drug delivery, matrix patches, diclofenac sodium, polyvinyl pyrrolidone, ethyl cellulose, in-vitro release
Abstract
The aim of the present study was to develop transdermal matrix patches with a fixed ratios of polyvinylpyrrolidone (PVP) and ethylcellulose (EC), containing the drug diclofenac sodium and to perform the physicochemical, in vitro relese pattern evaluation of the prepared patches. The prospective objective was the demonstration that the system provides the delivery of drug at a controlled rate across intact skin to achieve a therapeutically effective drug level for a longer period of time from transdermal patches.
References
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2. Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. 2008; 26(11):1261-1268.
3. Gaiwak AK. Transdermal drug delivery system: formulation aspects and evaluation Com. J. Pharm. Sci. 2013; 1(1):1-10.
4. Dhiman S, Singh TG, Rehni AK, Transdermal patches: a recent approach to new drug delivery system, Int J Pharm Sci. 2011; 3(5):26-34.
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7. Ozgurey IS, Karasulu HY, Kantarci G. Transdermal delivery of diclofenac sodium through rat skin from various formulations. AAPS Pharm Sci Tech. 2006; 7(4):E1-E7.
8. Mukherjee B, Das S, Patra B, Layek B. Nefopam containing transdermal matrix patches based on pressure sensitive adhesive polymers. Pharm. Technol. 2006; 30(3):146-163.
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10. Sahu RK, Jain A, Nayak S. Development and evaluation of transdermal patches of colchicine. Der. Pharm. Lettre. 2012; 4(1):330-343.
11. Manasadeepa R, Paul P, Mukherjee B. Pressure sensitive mucoadhesive polymer based dental patches to treat periodontal disease: an in vitro study. Drug Deliv. 2013; 20(6):258-267.
12. Arora P, Mukherjee B. Design, development, physicochemical and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt. J Pharm Sci. 2002; 91(9): 2076-2089.
13. Damodharan N, Roy G, Ghosh S, Mukherjee B. Skin permeation of rosiglitazone from transdermal matrix patches. Pharm Technol. 2010; 34(3):56-72.
2. Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. 2008; 26(11):1261-1268.
3. Gaiwak AK. Transdermal drug delivery system: formulation aspects and evaluation Com. J. Pharm. Sci. 2013; 1(1):1-10.
4. Dhiman S, Singh TG, Rehni AK, Transdermal patches: a recent approach to new drug delivery system, Int J Pharm Sci. 2011; 3(5):26-34.
5. Diclofenac transdermal patches: Medline Plus; https://medlineplus.gov/drug info/meds/a611001.html. Accessed on 6th December, 2016.
6. Bucci R, Magri AD, Magri AL. Determination of diclofenac salts in pharmaceutical formulations. Fresnius J Anal Chem. 1998; 362(7):2577-2582.
7. Ozgurey IS, Karasulu HY, Kantarci G. Transdermal delivery of diclofenac sodium through rat skin from various formulations. AAPS Pharm Sci Tech. 2006; 7(4):E1-E7.
8. Mukherjee B, Das S, Patra B, Layek B. Nefopam containing transdermal matrix patches based on pressure sensitive adhesive polymers. Pharm. Technol. 2006; 30(3):146-163.
9. Keith AD. Polymer matrix consideration for transdermal devices. Drug Deliv Ind Pharm. 1983; 9(4):605-621.
10. Sahu RK, Jain A, Nayak S. Development and evaluation of transdermal patches of colchicine. Der. Pharm. Lettre. 2012; 4(1):330-343.
11. Manasadeepa R, Paul P, Mukherjee B. Pressure sensitive mucoadhesive polymer based dental patches to treat periodontal disease: an in vitro study. Drug Deliv. 2013; 20(6):258-267.
12. Arora P, Mukherjee B. Design, development, physicochemical and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt. J Pharm Sci. 2002; 91(9): 2076-2089.
13. Damodharan N, Roy G, Ghosh S, Mukherjee B. Skin permeation of rosiglitazone from transdermal matrix patches. Pharm Technol. 2010; 34(3):56-72.
Published
2017-04-01
How to Cite
[1]
Das, S. 2017. Preparation and In-Vitro evaluation of Diclofenac Sodium Transdermal Patches. PharmaTutor. 5, 4 (Apr. 2017), 46-54.
Section
Articles
