Formulation and Evaluation of Atomoxetine Hydrochloride Sustained Release Tablets
Keywords:
Atomoxetine Hydrochloride, Sustained Release, tamarind seed polysaccharide, guar gum, PVP, Magnesium stearate, Microcrystalline cellulose
Abstract
Atomoxetine hydrochloride (atomoxetine) increased the risk of suicidal ideation in short-term studies in children or adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD). Tablets of Atomoxetine Hydrochloride were formulated as sustained release tablet employing tamarind seed polysaccharide, guar gum, PVP, Mg. stearate, MCC the sustained release tablets was investigated. Sustained release matrix tablets contain Atomoxetine Hydrochloride were developed using different drug polymer concentration of tamarind seed polysaccharide, guar gum.
References
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2. Alderman DA. Swellable matrices as systems for oral Delivery. Int J Pharm and Prod Mfr 1984; vol: 1-5.
3. Ashutosh Kumar S, Vijay Kumar G, Karthikeyan.M, Manidipa S, Ravisankar V, Arenachalam A. Formulation and evaluation of sustained release tablets of metoprolol succinate, Int J Pharm Bio Arch 2010;1(5):416-420.
4. Barretta GU, Nazzi S, Zambito Y, Gd C, Balzano F, Sanso M. Synergistic interaction between ts-polysaccharide and hyaluronic acid: Implications in the formulation of eye drops. Int J Pharma 2010;395:122-31.
5. Carpenter LL, Milosavljevic N, Schecter JM, Tyrka AR, Price LH: Augmentation with open-label atomoxetine for partial or nonresponse to antidepressants. J Clin Psychiatry. 2005 Oct;66(10):1234-8. Pubmed.
6. Chein YW. Novel drug delivery systems. 3rd Ed. New York: Marcel Dekker; 2002, p.139-96.
7. Chien YW. Rate controlled drug delivery systems. 2nd Ed. New York: Marcel Dekker.2005.
8. CIMS Book No: 07 Oct 2006- Jan 2007, 246- 8.
9. Costa P. An alternative method to the evaluation of similarity factor in dissolution testing. Int J Pharm 2001; 220:77-83.
10. Crowley MM et al. Physiochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion. Int J Pharm 2004; 269: 509-22.
11. Deveswaran R, Abrahum S, Basavaraj BV, Bharath S, Fartado S, Madhavan V. Design and characterization of diclofenac sodium tablets containing tamarind seed polysaccharide as release retardant. Int J Pharm Tech Res 2009;1(2):191-5.
12. Emami J, Tavakoli N, Movahedian A. Formulation of sustained-release lithium carbonate matrix tablets: influence of hydrophilic materials on the release rate and in vitro-in vivo evaluation. J Pharm Pharmaceut Sci 2004;7(3):338-44.
13. Erukulla. Durga Prasad, S. Indira M. Kranthi Kumar and M. Divya. Formulation and evaluation of buccoadhesive bilayered tablets of Atomoxetine hcl. Available at www.ijrpc.com (IJRPC 2012, 2(3), ISSN 2231-2781).
14. Gennaro AR (Ed.) Remington. The Science and Practice of Pharmacy, vol.II, 20th ed. New Delhi: Elsevier; 2000: p.903-07.
15. Ghosh S, Barik BB. Preparation and evaluation of Diclofenac sustained release formulation and comparison of formulated and marketed product. Int J Medicine Medical Science 2009;1(9):375-82.
16. Gilbert S, Banker C, Rhodes T. Modern Pharmaceutics. Vol. 121, 4th Ed. New York: Marcel Dekker Inc; 2008. p. 503-7.
17. Gomez AD. Role of water-uptake on tablet disintegration: design of improved method for penetration measurements, Acta Helv 1986;61(1):22-9.
18. Gul MK. Controlled release oral dosage forms: Some recent advances in matrix type drug delivery systems. The Sciences 2001;1(5):350-4.
19. Hajare AA, More HN, D‟Souza JI. Design and evaluation of sustained release tablets of diltiazem hydrochloride. Indian Drugs 2004;41(3):175-6.
20. Harborne JB. Phytochemical Methods: A guide to modern techniques of plant analysis. 3rd Ed. New Delhi: Springer (India) Pvt Ltd; 2007. p. 278-80.
21. Higuchi T. Mechanism of sustained action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sciences 1963; 52:1145-9.
22. Huda.I.G et al., has formulated the taste masked chewable dispersible tablets of atomoxetine hcl with eudragit EPO with a drug: avecil 101.The prepared batches of evaluation for hardness, friability, drug content uniformity and invitro dispersion time. 2012 ,2(2):110-5.
23. http://www.mhra.gov.uk/home/groups/lunit1/documents/websiteresources/con.... pdf.
24. http://www.pharmainfo.net/reviews/tamarind-seed-polysaccharides-novel-ca... drug-delivery-systems.
25. ICH Q1A (R2) stability testing guidelines: stability testing of new drug substances and products. [Online]. 2003 [cited 2008 Nov10]; Available from: 26. URL:http://www.tga.health.gov.au/docs/pdf/euguide/inch/273699r2en.pdf.
26. Indian Pharmacopoeia, volume 1. Ministry of Health and Family Welfare. New Delhi: Controller of Publications; 2007; p. 477-8.
Published
2017-05-01
How to Cite
[1]
Farheen, S., Zubair, S., Arpini, A., Goud, G., Soppari, S. and Kethavath, M. 2017. Formulation and Evaluation of Atomoxetine Hydrochloride Sustained Release Tablets. PharmaTutor. 5, 5 (May 2017), 76-92.
Section
Articles
