Niosomes as Novel Drug Delivery System: Review Article

  • Devender Sharma Hi-Tech College of pharmacy
  • Aashiya Aara E. Ali Kamla Nehru College of pharmacy
  • Jayshree R. Aate Hi-Tech College of pharmacy
Keywords: Niosomes, Compositions, Methods of Preparation, Encapsulation, Surfactants, Vesicles and Applications

Abstract

Niosome are non-ionic surfactant vesicles obtained by hydrating mixture of cholesterol and nonionic surfactants. It can be used as carriers of amphiphilic and lipophilic drug. In niosomes drug delivery system, the medication is encapsulated in a vesicle. Niosomes are biodegradable, biocompatible non-immunogenic and exhibit flexibility in their structural characterization. The main object of this review the application of niosome technology is used to treat a number of diseases, niosome have good opportunity in research and beneficial for researcher and pharma industries.  Niosome appears to be a well preferred drug delivery system over liposome as niosome being stable and economic. Also niosomes have great drug delivery potential for targeted delivery of anti-cancer, anti-infective agents. Drug delivery potential of niosome can enhances by using novel drug delivery concepts like proniosomes, discomes and aspasome. Niosomes also serve better aid in diagnostic imaging and as a vaccine adjuvant. Thus these areas need further exploration and research so as to bring out or to make for commercially available niosomal preparation.

Author Biographies

Devender Sharma, Hi-Tech College of pharmacy

Hi-Tech College of pharmacy,
Chandrapur, Maharashtra, India

Aashiya Aara E. Ali, Kamla Nehru College of pharmacy

Kamla Nehru College of pharmacy,
Nagpur, Maharashtra, India

Jayshree R. Aate, Hi-Tech College of pharmacy

Hi-Tech College of pharmacy,
Chandrapur, Maharashtra, India

References

1. Gayatri Devi S, Venkatesh P, Udupa N. Niosomal sumatriptan succinate for nasal administration. Int J Pharm Sci 2000;62:479-81.
2. Baillie AJ., Florence AT., Hume LR., Muirhead GT., Rogerson A., The preparation and properties of niosomes non-ionic surfactant vesicles. J. Pharm. Pharmacol. 1985, 37: 863- 868.
3. Hunter CA, Dolan TF, Coombs G, Baillie AJ. Vesicular systems (niosomes and liposomes) for delivery of sodium stibogluconate in experimental murine visceral leishmaniasis. J Pharm Pharmacol 1988; 40:161-5.
4. Khandare JN., Madhavi G., Tamhankar BM., Niosomes Novel Drug Delivery System. The Eastern Pharmacist. 1994, 37: 61-64.
5. http//en.wikipedia.org/wiki/Niosomes, structure of niosomes.
6. Rogerson A., Cummings J., Willmott N., Florence AT., The distribution of doxorubicin in mice following administration in niosomes. J. Pharm. Pharmacol. 1988, 40: 337-342.
7. Biju SS., Talegaonkar S., Misra PR., Khar RK., Vesicular systems: An overview. Indian J. Pharm. Sci. 2006, 68: 141-153.
8. Ijeoma F., Uchegbu., Suresh P., Vyas., Non-ionic surfactant based vesicles (niosomes) in drug delivery. Int. J. Pharm. 1998; 172: 33–70.
9. Malhotra M., Jain N.K., Niosomes as Drug Carriers. Indian Drugs. 1994, 31(3): 81-866.
10. Alsarra A., Bosela A,, Ahmed S.M,, Mahrous G.M., Proniosomes as a drug carrier for transdermal delivery of ketorolac. Eur. J. Pharm. And Biopharm. 2004; 2(1): 1-6.
11. Hu C., Rhodes D.G., Proniosomes: a novel drug carrier preparation. Int. J. Pharm. 1999, 185: 23-35.
12. Breimer DD and Speiser R. Topics in Pharmaceutical Sciences. Elsevier Science Publishers, New York, USA. 1985;291.
13. Handjani VRM. Dispersion of Lamellar Phases of Nonionic Lipids in Cosmetic Products. Int J Cosmetic Sc. 1979;30.
14. Sternberg B, Uchegbu IF, Florence AT and Murdan S. 1998.
15. Theresa MA. Drugs published by ADIS international Ltd. 1998; 56(5):747-756.
16. Buckton G and Harwood. Interfacial Phenomena in Drug Delivery and Targeting Academic Publishers, Switzerland. 1995;154-155.
17. Shahiwala A and Misra A. Studies in Topical Application of Niosomally Entrapped Nimesulide. J Pharma Sci. 2002;220.
18. Reddy DN and Udupa N. Formulation and Evaluation of Oral and Transdermal Preparation of Flurbiprofen and Piroxicam Incorporated with Different Carriers. Drug Dev Ind Pharm. 1993; 843.
19. Satturwar P M. Formulation and Evaluation of Ketoconazole Niosomes. Ind J Pharm Sci. 2002; 155.
20. Azmin MN, Florence AT, Handjani-Vila RM, Stuart JF, Vanlerberghe G, Whittaker JS. The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. J Pharm Pharmacol 2005;37:237-42.
21. Weissman G, Bloomgarden D, Kaplan R, Cohen C, Hoffstein S, Collins T, et al. A general method for the introduction of enzymes, by means of immunoglobulin-coated liposomes, into lysosomes of deficient cells. Proc Natl Acad Sci 1975;72:88-92.
22. Navneet Kumar Verma, Asha Roshan. Niosomes and its application:A Review, IJRPLS, 2014; 2(1): 182-184
Published
2018-03-01
How to Cite
[1]
Sharma, D., Ali, A.A.E. and Aate, J.R. 2018. Niosomes as Novel Drug Delivery System: Review Article. PharmaTutor. 6, 3 (Mar. 2018), 58-65. DOI:https://doi.org/10.29161/PT.v6.i3.2018.58.
Section
Articles

Most read articles by the same author(s)