A Review: Effect of Diabetes on Vascular Endothelium
Keywords:
: Diabetes, Endothelial dysfunction, Endothelium-derived hyperpolarizing facto
Abstract
Endothelial dysfunction is mainly observed in diabetics. The main role of endothelium is to control the tone of the vascular smooth muscle through the production of vasodilator mediators like nitric oxide (NO), prostacyclin, and endothelium-derived hyperpolarizing factor (EDHF). Impaired endothelium-dependent vasodilation has been observed in vascular beds of different animal models of diabetes and in humans with type 1 and 2 diabetes. Hyperglycaemia causes repeated acute changes in intracellular metabolism and causes activation of polyol pathway, activation of protein kinase C, advanced glycation end product and increased oxidative stress.
References
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3. Guerci B, Bohme P, Schwartz AK, Zannad F, Drouin P. Endothelial Dysfunction and Type 2 Diabetes Part 2: altered endothelial function and the effects of treatments in type 2 diabetes mellitus. Diabetes Metab (Paris). 2001; 27: 436-47.
2. Hsueh WA, Lyon CJ, Quinones MJ. Review Insulin Resistance and the Endothelium. The Am J Med. 2004; 117: 109-14.
3. Guerci B, Bohme P, Schwartz AK, Zannad F, Drouin P. Endothelial Dysfunction and Type 2 Diabetes Part 2: altered endothelial function and the effects of treatments in type 2 diabetes mellitus. Diabetes Metab (Paris). 2001; 27: 436-47.
Published
2014-03-05
How to Cite
[1]
Patil, Y. 2014. A Review: Effect of Diabetes on Vascular Endothelium. PharmaTutor. 2, 3 (Mar. 2014), 72-75.
Section
Articles
