Benzimidazole Derivatives and its Biological Importance: A Review
Keywords:
Benzimidazoles, Chemistry, Medicinal Drugs, Importance
Abstract
Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and imidazole. Heterocyclic compounds are occupied prominent place among various class of aromatic organic compounds. Benzimidazole are having a variety of therapeutic uses including antitumor, antifungal, antiparasitic, analgesics, antiviral, antihistamine, as well as use in cardiovascular disease, neurology, endocrinology, and ophthalmology.
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2. Grassi A, Ippen J, Bruno M, Thomas G and Bay P. thiazolylamino benzimidazole derivative with gastroprotective properties in the rat. Eur J Pharmacol.1991;195(2):251-9.
3. Ozkay Y, Tunali Y, Karaca H. and Isikdag I. Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazones moiety. European Journal of Medicinal Chemistry. 2010;45(8):3293-3298.
4. Preston P N, Stevens M F G & Tennant G, Benzimidazoles and Congeneric Tricyclic Compounds, Part 2, (John iley and Sons New York) 1980;
5. Metwally KA, Abdel-Aziz LM, Lashine el-SM, Husseiny MI and Badawy RH. Hydrazones of 2-aryl- -4- carboxylic acid hydrazides: synthesis and preliminary evaluation as antimicrobial agents. Bioorg Med Chem. 2006;14(24): 8675-82.
6. Spasov A, Yozhitsa L, Bugaeva I and Anisimova VA. Benzimidazole derivatives: Spectrum of pharmacological activity and toxicological properties. Pharmaceutical Chemistry Journal. 33;5:232-243.
7. Arjmand F, Mohani B and Ahmad S. Synthesis, antibacterial, antifungal activity and interaction of CT-DNA with a new benzimidazole derived Cu (II) complex. Eur J Med Chem. 2005;40(11):1103-1110.
8. Dudd L M, Venardou E, Garcia-Verdugo E, Licence P, Blake A J, Wilson C & Poliakoff M, Green Chem, 5, 2003, 187.
9. Nagata K, Itoh T, Ishikawa H & Ohsawa A, Heterocycles,61, 2003, 93.
10. Curini M, Epifano F, Montanari F, Rosati O & Taccone S, Synlett, 18, 2004, 32.
11. Chakrabarty M, Karmakar S, Ajanta M, Arima S & Harigaya Y, Heterocycles,68, 2006, 967.
12. Aliyan H, Fazaeli R, Fazaeli N, Mssah A R, Naghash H J, Alizadeh M & Emami G, Heteroatom Chem, 20, 2009, 202.
13. Zhang Z H, Yin L & Wang Y M, Catal Commun,8, 2007, 1126.
14. E. C. Wagner and W. H. Millett (1943), "Benzimidazole", Org. Synth.; Coll. Vol. 2: 65.
15. Khan Farhan. R., Asnani A. J.et.al ,International Journal of Research in Pharmaceutical and Biomedical Sciences. 2011, Vol. 2 (2)
16. Canan KUS .,Turk J Chem 26, 2002 , 559 – 564.
17. Canan KUS .,Turk J Chem 27, 2003 , 35 – 39.
18. Hasan K¨UC¸¨UKBAY, ¨Ulku¨YILMAZ., Turk J Chem 35 (2011) , 561 – 571.
19. Michile tonilli et.al.Bio-organic & medicinal chemistry 18 (2010) 2937-2953.
20. B. Guruswamy and R. Arul., Der Pharma Chemica, 2011, 3 (6):483-486
21. DT Nannapaneni, Atyam VSSS Gupta,1 MI Reddy, and Raidu Ch Sarva1 J Young Pharm. 2010 Jul-Sep; 2(3): 273–279.
22. Balram Soni, Mahendra Singh Ranawat1, Anil Bhandari2 and Rambabu Sharma ., Int. J. Drug Res. Tech. 2012, 2 (7), 479-485.
Published
2014-03-05
How to Cite
[1]
Yerragunta, V., Gayathri, R., Srujana, S., patil, P., Srujana, S., Devi, R. and Divya, A. 2014. Benzimidazole Derivatives and its Biological Importance: A Review. PharmaTutor. 2, 3 (Mar. 2014), 109-113.
Section
Articles
