A Review : Introduction of Effervescent Tablet and their Quality Control test

  • Brijesh Dasvani Parul Institute of Pharmacy
  • Avani Khristi Parul Institute of Pharmacy
Keywords: Floating drug Delivery System, Effervescent Tablet, Sustained release


Oral dosage forms are the best medicine administration way of taking medication, despite having some disadvantages compared with other methods like risk of slow absorption of the medicament, which can be overcome by administering the drug in liquid form, therefore, possibly allowing the use of a lower dosage. However, instability of many drugs in liquid dosage form limits its use. Effervescent technique can be used as alternate to develop a dosage form which can accelerate drug disintegration and dissolution, is usually applied in quick release preparations. Along with the development of new pharmaceutical technique, effervescent tablet are more and more extensively to adjust the behaviour of drug release, such as in sustained and controlled release preparations, pulsatile drug delivery systems, and so on.

Author Biographies

Brijesh Dasvani, Parul Institute of Pharmacy

Parul Institute of Pharmacy,
Waghodiya,Limda, Vadodara, Gujarat, India

Avani Khristi, Parul Institute of Pharmacy

Parul Institute of Pharmacy,
Waghodiya,Limda, Vadodara, Gujarat, India


1. Abdul AS (2012); Formulation, Evaluation and Mathematical Modeling of Clopidogrel Bisulphate & Aspirin Immediate Release Bilayer Tablets; Pharmaceutca Anal Acta; 3(9); 194.
2. Abolfazl A, (2013); Characterization and Physicochemical Evaluation of Ranitidine Effervescent Tablets; Advanced Pharmaceutical Bulletin, 3(2); 315-322.
3. Aboud HM, Elbary A, Ali AA, (2012); Enhanced dissolution of meloxicam from orodispersible tablets prepared by different methods, Bulletin of Faculty of Pharmacy, Cairo University; 50(2); 89–97.
4. Agyilirah GA, Green M, DuCret R, Banker GS, (1991); Evaluation of the gastric retention properties of a cross-linked polymer coated tablet versus those of a non-disintegrating tablet; International Journal of Pharmaceutics; 75(2-3); 241–47.
5. Ahmed I, Aboul-Einien M, (2007); In vitro and in vivo evaluation of a fast disintegrating lyophilized dry emulsion tablet containing griseofulvin; European Journal of Pharmaceutical Sciences; 32(1); 58-68
6. Aly AM, Amro BI, Hajji FD, (2011); Preparation and Evaluation of Rapidly Disintegrating Glimepiride Tablets; International Journal of Pharmaceutical Sciences and Nanotechnology; 3(4);1220-1229.
7. Ashish P, Harsoliya MS, Pathan JK, Shruti S, (2016); A Review- Bhattacharjee J. Mass Drugs Administration in India - A Failure Story; Epidemiology Sunnyvale; 6; 252.
8. Biswas D and Halquist M, (2016); Using Biorelevant in Vitro Models Testing to Characterize Release of Non Oral Dosage Forms as another Tool for Safety; Journal of Pharmacovigilance; 4(2); 153-160.
9. Cho SK. (2015); The Synergistic Effects of Pioglitazone on the Glucose-Lowering Action of Metformin in Relation to OCT1 and Gluts m-RNA Expression in Healthy Volunteer; Clinical Pharmacology and Biopharmaceutics; 3;129.
10. Deepali DW, Madhav MS, Jain DS, (2011), Gastroretentive Floating Microspheres: A Review, International Journal Of Pharmacy &Technology, 3(4):1783-1799.
11. Dhakar RC, Maurya SD, Aggarawal S, Kumar G, Tilak VK, (2010); Design and evaluation of SRM microspheres of Metformin hydrochloride; Pharmacie Globale(IJCP), 1(07); 1-6.
12. Dhakar RC, Maurya SD, Dangi G, Kumar G , Gupta M, Kiroriwal S, (2010); Buccal Adhesive Dosage Forms As A NISDD: A Pharmaceutical Review; Research Pharmaceutica; 1(1); 46-59.
13. Dhakar RC, Maurya SD, Gupta AK, Siddiqui AW, (2010); Interpenetrating polymeric network hydrogel for stomach-specific drug delivery of clarithromycin: Preparation and evaluation; Asian Journal of Pharmaceutics; 4(4); 184-189.
14. Dhakar RC, Maurya SD, Sagar BPS, Prajapati SK, Jain CP, (2010); Variables influencing the drug entrapment efficiency of microspheres: a pharmaceutical review; Der Pharmacia Lettre; 2(5);102-116.
15. Dixit N, Maurya SD, Sagar BPS, (2013); Sustained release drug delivery system; Indian Journal of Research in Pharmacy and Biotechnology; 1(3); 305-310.
16. Ehrenpreis ED, (2014); A Survey of Lawsuits Filed for the Complaint of Tardive Dyskinesia Following Treatment with Foldvari M, Nanopharmaceutics Innovations in Gene Therapy: Moving Towards Non-Viral and Non-Invasive Delivery Methods; J Nanomedine Biotherapeutic Discovery; 4;135.
17. Gharti KP, Thapa P, Budhathoki U, Bhargava A, (2009); Formulation and in vitro evaluation of floating tablets of hydroxypropyl methylcellulose and polyethylene oxide using ranitidine hydrochloride as a model drug, Journal of Young Pharmacists; 4(4); 201-208.
18. Harald S, (2003); Effervescent Dosage; Pharmaceutical Technology Europe; 15(4); 25–28.
19. Hassali MA, (2016); Role of Pharmacists in Health Based Non-Governmental Organizations NGO: Prospects and Future Directions, Pharm Anal Acta; 7(2);467.
20. Howard CA, Lloyd A, Nocholas and Popovich, (2000); “Effervescent granules”8th edition “Pharmaceutical Dosage From and Drug Delivery” International Student Edition.- 172-178.
21. Indian Pharmacopoeia, (1996); Government of India Ministry of Health and Family Welfare;Delhi: Controller of Publications 2: 35; 448, 554.
22. Kokardekar RR, (2014); Development and Evaluation of Sustained Release Microspheres of Glibenclamide by Emulsion Solvent Evaporation Method; Clinical Pharmacology and Biopharmaceutics; 3; 127.
23. Lachman L, Liberman HA, Kanig JL, (1986); The theory and practice of industrial pharmacy. 3rd ed. Philadelphia: lea and febiger.
24. Larry LA and Stephan WH, (1993); Pharmaceutical Dosage Form: Tablets 3rd edition Vol. 1:. Nanoimaging for Molecular Pharmaceutics; 465.
25. Maurya SD, Rawal RK, Jha S, Chauhan PS, Kumar A, (2013); Drug Loaded Beads: Current; American Journal of Pharm Tech Research, 3 (1); 331-337.
26. Marcel Dekker; Teoh BC, et al. (2015); Perceptions of Doctors and Pharmacists towards Medication Error Reporting and Prevention in Kedah, Malaysia: A Rasch Model Analysis; AdvPharmacoepidemiol Drug Saf; 4(5); 192
27. Maurya SD, Tilak VK, Dhakar RC, Verma KK, Soni U, Gupta, (2011); Preparation and evaluation of floating tablet of famotidine through solid dispersion; International Journal of Current Research and Review; 2(1); 21-30.
28. Mohrle, R., Liberman, L,Schwartz L, (2005); Pharmaceutical Dosage Form; Marcel Decker Inc; New York; 1; 285- 292.
29. Obara T, Prevalence, (2015); Determinants, and Reasons for the Non-Reporting of Adverse Drug Reactions by Pharmacists in the Miyagi and Hokkaido Regions of Japan; Advance Pharmacoepidemiology and Drug Safety; 4(5);191.
30. Patil JS, (2000); Hydrogel System An Approach for Drug Delivery Modulation; Advance Pharmacoepidemiology and Drug Safety, 4(5);135.
31. Patil JS, (2015); Novel Tubercular Therapeutic Agents: Need of the Day; Advance Pharmacoepidemiology and Drug Safety; 4(5); 137
32. Sallam A, (2015); Bioequivalence of Two Oral Formulations of Modafinil Tablets in Healthy Male Subjects under Fed and Fasting Conditions; Journal of Bioequivalence Availability; 7(2);63-67.
33. Sandhyarani G, Kumar KP, (2017); Formulation and evaluation of fast dissolving Tablet of imidapril, Indian Journal of Pharmaceutical Science& Research; 4(3); 147-150.
34. Sastry SV, Nyshdham JR, Fix JA, (2000); Recent technological advances in oral drug delivery: A review; Pharmaceutical Science and Technology Today, 1(3); 38-45.
35. Shimodaira S, (2016); Quality Verification of Dendritic Cell-Based Cancer Vaccine; Pharm Anal Acta; 7(2); 467.
36. Simona B, Tanja R, (2010); Using different experimental designs in drug excipient Compatibility Studies during the Pre-formulation development of a stable solid dosage formulation; Acta Chimica Slovenica; 57(4); 895-903.
37. Singh BN, Kim KH, (2000); Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention; Journal of Controlled release; 63(3);235–59.
38. Singh LP, Rajesh KS, Umalkar DG, Chauhan VK, Rana VK, Vasava KS, (2011); Floating Effervescent Tablet : A Review; Journal of pharmaceutical and biomedical sciences; 5(11); 1-6.
39. Skalkz BN, Srinath KR, (2016); Note on the “Molecular Pharmaceutics and “Formulation and Evaluation of Effervescent tablets of Paracetamol”, International Journal of Swain S and Beg S. Emergence in the Lipid-Based Nanostructured Systems for Optimizing Oral Delivery of Drugs; Pharmaceutical Regulatory Affairs; 5;157-163.
40. Swarbrick J, Boylan JC. (2002); Encyclopaedia of pharmaceutical technology; New York.
41. Thoke SB, Sharma Y., Rawat S, Nangude, S (2013); Formulation development & evaluation of effervescent tablet of Alendronate sodium with vitamin D3; Journal of Drug Delivery & Therapeutics;; 3(5); 65-74.
42. United States Pharmacopeia 31/National Formulary 26. (2008); Rockville MD USA: United States Pharmacopeial Convention.
43. Vergeire DG, (2016); Usefulness of Cost Effectiveness: Evidence versus Applicability; Pharm Anal Acta, 7(1); 456.
44. Yanze FM, Duru C, Jacob M, (2000); A process to produce effervescent tablets: Fluidized bed dryer melt granulation; Drug Development & Industrial Pharmacy, 26(11);1167-76.
How to Cite
Dasvani, B. and Khristi, A. 2019. A Review : Introduction of Effervescent Tablet and their Quality Control test. PharmaTutor. 7, 9 (Sep. 2019), 28-33.