Solubility Enhancement of Poorly Water Soluble Drug Celecoxib

Abstract

Poorly water-soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Improvement in the extent and rate of dissolution is highly desirable for such compounds, as this can lead to an increased and more re-producible oral bioavailability and subsequently to clinically relevant dose reduction and more reliable therapy. More than 40% of newly discovered drugs have little or no water solubility presents a serious challenge to the successful development and commercialization of new drugs in the pharmaceutical industry. Now a days, pharmaceutical technology provides many approaches to enhance the dissolution rate of poorly soluble drugs. Physical modifications often aim to increase the surface area, solubility and/or wet ability of the powder particles and are therefore focused on particle size reduction or generation of amorphous states [Hancock, 1997 & Grau, 2000]. Several methods have been employed to improve the solubility of poorly water soluble drugs. A solid dispersion technique has been used by various researchers who have reported encouraging results with different drugs. The first drug whose rate and extent of absorption was significantly enhanced using the solid dispersion technique was sulfathiazole by Sekiguchi and Obi (Sekiguchi, 1961).