Enhancement of Solubility Characteristics of Alprazolam
Abstract
Alprazolam is an anti-anxiety with sedative and hypnotic actions and used in treatment of anxiety and panic disorders. It is practically insoluble in water and hence has a less bioavailability. In the present study attempt has been made to prepare and characterize inclusion complexes of alprazolam with HP-β-CD and PEG6000 (Polyethylene glycol6000). The phase solubility analysis indicated the formation of 1:1 molar inclusion complex of alprazolam with HP-β-CD and PEG6000. The inclusion complexes were prepared by two different methods viz. physical and kneading methods. The complexes were characterized using Fourier transform infrared spectroscopy and differential scanning calorimetry. The complexes prepared by physical method with HP-β-CD exhibited greatest enhancement in solubility and fastest drug release of 90.29% and kneading method with PEG6000 exhibited greatest enhancement in solubility and fastest drug release of 90.19%.
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