A Review on Osmotically Regulated Systems
Keywords:
Osmosis, Controlled drug delivery system, osmotic pump, osmogens, semi permeable membrane
Abstract
Osmotic devices are most promising strategy based systems for controlled drug delivery. They are among the most reliable controlled drug delivery systems and could be employed as oral drug delivery systems or implant able devices. Osmotic pumps offer many advantages over other controlled drug delivery systems, i.e. they are easy to formulate and simple in operation, improve patient compliance with reduced dosing frequency and more consistent and prolonged therapeutic effect with uniform blood concentration. Drugs can be delivered in a controlled pattern over a long period of time by the process of osmosis. Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semi permeable membrane. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. This article highlights the principle of osmosis, materials used for fabrication of pumps, types of pumps, advantages, disadvantages, and marketed products of this system.
References
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29.Longxiao Liu, Jeong Ku, Gilson Khang, Bong Lee, John M Rhee, Hai Bang Lee. Journal of Controlled Release 2000; 68: 145–156.
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31.Wong P S I, Barclay B, Deters J C and Theeuwes F; Osmotic device with dual thermodynamic activity. US Patent 4612008; 1986.
32.Ghosh Tanmoy, Ghosh Amitava. “A review on drug delivery through osmotic systems.” J. Of applied pharmaceutical science (JAPS).2011; 01(02):38-49.
33. Sudeesh E: Formulation development and optimization of controlled porosity osmotic pump tablets of diclofenac sodium. International Journal of Pharmacy and Pharmaceutical Sciences 2011; 3(1): 80-87.
34.Prakash RB, Geetha M, Purushothama N, Utpal S: Optimization and Development of Swellable Controlled Porosity Osmotic Pump Tablet for Theophylline. Tropical Journal of Pharmaceutical Research 2009; 8(3) 247-255.
35.Nikam PH, Kareparamban, Jadhav AP, Kadam VJ., “A review on osmotic pump: A Reliable drug delivery system. Research J. Of pharmaceutical, Biological Chemical Sciences (RJPBCS).2012; 3(3):478-493.
36.Mahalaxmi R, Phanidhar S, Ravikumar, Atin K, Pritam K, Narkhede: Enhancement of Dissolution of Glipizide from Controlled Porosity Osmotic Pump Using a Wicking Agent and a Solubilizing Agent International Journal of PharmTech Research 2009;13): 705
37.GM Zentner, GS Rork, KJ Himmelstein. US patent 4, 1990,968,507
38.Gaebler F; Laser drilling enables advanced drug delivery systems, Coherent article for Pharmaceutical Manufacturing, Jan-2007, 1-7.
39.Speers M, Bonnano C. Economic aspects of controlled drug delivery. In: Mathiowitz E,
ed. Encyclopedia of Controlled Drug Delivery. New York, NY: Wiley; 1999:341Y347
40.Eckenhoff, Yum SI: The osmotic pump: novel research tool for optimizing drug regimen. Biomaterials, 1981; 2:89-97
2.Theeuwes F, Swanson D R, Guitttard G, Ayer A, Khanna S; Osmotic delivery systems for the β-adrenoceptor antagonists Metoprolol and Oxprenolol: Design and evaluation of systems for once-daily administration. Br. J Clin Pharmacology. 1985; 19, 69-76.
3.Santus G, Baker R W; Osmotic drug delivery: A review of the patent literature. J Control Release, 1995, 35, 1-21.
4.Verma R K, Mishra B, Garg S; Osmotically controlled oral drug delivery. Drug Dev Ind Pharm. 2000; 26(7):695-708.
5. Prescott L F; The need for improved drug delivery in clinical practice, In: Novel Drug Delivery and Its Therapeutic application, John Wiley and Sons, West Susset, UK, 1989, 1-11.
6.Dr Bhatt P P; Osmotic drug delivery systems for poorly water soluble drugs Pharmaventures Ltd., Oxford, UK, 2004; 26-29
7.Pfefer, W E P; Osmotishe Umtersuchen, Leipzig. 1877; 232
8.Li X and Jasti B R; Osmotic controlled drug delivery systems, In: Design of controlled release of drug delivery systems, McGraw Hill, 2006; 203-229.
9. Rastogi S K, Vaya N, Mishra B; Osmotic pump: A novel concept in rate controlled oral drug delivery. Eastern pharmacist. 1995; (38):79-82.
10.Fix J, In: Encyclopedia of controlled drug delivery, Edmathiowitz, vol-2, John Wiley and sons, Inc 700.
11. Kaushal A M and Garg S; An update on osmotic drug delivery patents, Pharm Tech. Aug 2003; 38-44.
12.Lachman L., Liberman H. A., Kanig J. L., The theory and practise of industrial pharmacy. 2nd Edition 1991, Varghese publishing house, P=455
13.Stuti G, Ravindra PS, Rohitashva S. International Journal of Comprehensive Pharmacy 2011; 6: 1.
14.NK Jain. Advances in controlled and novel drug delivery, CBS Publisher & distributer, first adition. Page No.20
15.Theuwes F., Swanson D. R., Guitttard G. and Ayer A. (1985). Br. J.Clin. Pharmacology, 19, 69-76.
16.Parashar Bharat, Maurya Brajesh, Yadav Virendra, Sharma Love. “A review on osmotically regulated devices.” The pharma innovation.2012; 1(4):48-56.
17.Gadwal P, Rudrawal P. International Journal of Pharmacy & Life Sciences 2010; 1(6): 302-312.
18.Ouyang D, Nie S, Li W, Guo H, Liu H, Pan W. J Pharm Pharmacol 2005; (57): 817-820.
19.Tanmoy Ghosh, Amitava Ghosh. Journal of Applied Pharmaceutical Science 2011; 1 (2): 38-49
20.F Theeuwes. Journal of Pharmaceutical Sciences 1975; (64): 1987– 1991.
21.Mane Suraj S., Kamble Meghana S., Chaudhari Pravin D., Bhosale Ashok V., “A review on oral osmotically controlled drug delivery system.” International J. Of universal pharmacy and life sciences (IJUPLS).2012; 2(2):19-36
22.Parma NS, Vyas SK, NK Jain. In: Advanced in controlled and novel drug delivery. CBS publisher, 28-29.
23.Dong L, Shafi K, Wan J, Wong; In: Proceeding of the international symposium on controlled release of bioactive material, paris (july) 2003.
24.Cortese R and Theeuwes F; Osmotic device with hydro gel driving member. US Patent 4327725; 1982.
25.Javad Shokri, Parinaz Ahmadi, Parisa Rashidi, Mahbobeh Shahsavari, Ali Rajabi-Siahboomi, Ali Nokhodchi. European Journal of Pharmaceutics and Biopharmaceutics 2008; 68: 289–297.
26.Gaylen Zentner M, Gerald S Rork and Kenneth J Himmerstein; The Controlled Porosity Osmotic Pump. J Control Rel. 1985: 1: 269-282.
27.Kaushal, Aditya and Garg Sanjay. Pharma Technol 2003; 27: 39.
28.Theeuwes F, Wong P S L, Burkoth T L and Fox D A; Osmotic systems for colon-targeted drug delivery. In: Colonic drug absorption and metabolism. Marcel Dekker, NY, 1993; 137-158.
29.Longxiao Liu, Jeong Ku, Gilson Khang, Bong Lee, John M Rhee, Hai Bang Lee. Journal of Controlled Release 2000; 68: 145–156.
30.Patel Harnish, Patel Upendra, Kadikar Hiren, Bhimani Bhavin, Daslaniya Dhiren, Patel Ghanshyam. “A review on osmotic drug delivery system.” International research J. Of pharmacy (IRJP).2012; 3(4):88-94.
31.Wong P S I, Barclay B, Deters J C and Theeuwes F; Osmotic device with dual thermodynamic activity. US Patent 4612008; 1986.
32.Ghosh Tanmoy, Ghosh Amitava. “A review on drug delivery through osmotic systems.” J. Of applied pharmaceutical science (JAPS).2011; 01(02):38-49.
33. Sudeesh E: Formulation development and optimization of controlled porosity osmotic pump tablets of diclofenac sodium. International Journal of Pharmacy and Pharmaceutical Sciences 2011; 3(1): 80-87.
34.Prakash RB, Geetha M, Purushothama N, Utpal S: Optimization and Development of Swellable Controlled Porosity Osmotic Pump Tablet for Theophylline. Tropical Journal of Pharmaceutical Research 2009; 8(3) 247-255.
35.Nikam PH, Kareparamban, Jadhav AP, Kadam VJ., “A review on osmotic pump: A Reliable drug delivery system. Research J. Of pharmaceutical, Biological Chemical Sciences (RJPBCS).2012; 3(3):478-493.
36.Mahalaxmi R, Phanidhar S, Ravikumar, Atin K, Pritam K, Narkhede: Enhancement of Dissolution of Glipizide from Controlled Porosity Osmotic Pump Using a Wicking Agent and a Solubilizing Agent International Journal of PharmTech Research 2009;13): 705
37.GM Zentner, GS Rork, KJ Himmelstein. US patent 4, 1990,968,507
38.Gaebler F; Laser drilling enables advanced drug delivery systems, Coherent article for Pharmaceutical Manufacturing, Jan-2007, 1-7.
39.Speers M, Bonnano C. Economic aspects of controlled drug delivery. In: Mathiowitz E,
ed. Encyclopedia of Controlled Drug Delivery. New York, NY: Wiley; 1999:341Y347
40.Eckenhoff, Yum SI: The osmotic pump: novel research tool for optimizing drug regimen. Biomaterials, 1981; 2:89-97
Published
2014-05-01
How to Cite
[1]
Farheen, F. and Bharadwaj, S. 2014. A Review on Osmotically Regulated Systems. PharmaTutor. 2, 5 (May 2014), 51-64.
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