Three dimensional (3D) drug printing: A revolution in pharmaceutical science

  • Mohamed Mazhar Delhi Pharmaceutical Sciences & Research University
  • Ubaid Tariq
Keywords: USFDA, personalized medicine, manufacturing, Three dimensional printing


Three-dimensional (3D) printing is a manufacturing method in which objects are made by fusing or depositing materials in successive layers laid down under computer control. These objects can be of almost any shape or geometry and are produced from a 3D model as defined in a computer-aided design (CAD). Since the inception of 3D printing in 1984 it has evolved immensely and has been used in many fields including medicine, architecture and more recently in pharmaceutical manufacturing. From lab grown organs to drug delivery devices, 3D printing is advancing rapidly and in future course of time it is going to transform and change the way we live and work.

3D printing in pharmaceuticals has been used to produce many novel dosage forms like microcapsules, Complex Drug-Release Profiles, nanosuspensions, and multilayered drug delivery devices. From industrial point of view it also offers important advantages like, cost-effectiveness, increased productivity, democratization of design and manufacturing, and enhanced collaboration.

Keeping in view the recent approval given by USFDA to the first 3D printed antiepileptic drug the focus has now shifted to the personalized medicine as it offers an important benefit to patients who need medications that have narrow therapeutic indices or a higher predilection to be influenced by genetic polymorphisms. 3D printer is now seen as a valuable, efficient and economical tool to manufacture individualized medications, tailored to specific patients based on their needs and thereby change the future of pharmacy practice in general and pharmaceutical care in particular.


Alford PW, Feinberg AW, Sheehy SP, Parker KK. ( 2010); Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials.;31(13); 3613–3621

Alvaro Goyanes, Pamela Robles Martinez, Asma Buanz, et al. (2015); Effect of geometry on drug release from 3D printed tablets. International Journal of Pharmaceutics.; 494(2); 657-663

AV Plastics; 3D Printing History. (Accessed 12- june-2017)

A BRIEF HISTORY OF 3D PRINTING. (Accessed 12- june-2017)

C. Lee Ventola. (2014); Medial applications of 3D printing: Current and Projected use. P&T ; 39(10); 704-711

Dominic Basulto. Why it matters that the FDA just approved the first 3D-printed drug. 11-Aug.-2015 (Accessed 12- june-2017)

Dr. Hartmut Stahl. 3D Printing – Risks & Opportunities. oKo- institute e.V. 2013-Dec.-05. 532-en

Lee H, Cho D-W. (2016); One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology. Lab Chip. ;16(14); 2618–2625.

Mazhar, M., Ansari, A. and Rajput, S.K., (2015); Clinical pharmacy in India: recent advances and perspective; PharmaTutor; 3(3); pp.31-36.

Nagarajan N, Dupret-Bories A, Karabulut E, Zorlutuna P, Vrana NI. (2018); Enabling personalized implant and controllable biosystem development through 3D printing. Biotechnol Adv; 36(2); 521–533

Razelle Kurzrock, David J. Stewart. (2015); Click chemistry, 3D-printing, and omics: the furure of drug development; Oncotarget.; 7(3); 2155-2158

Robert J. Szczebra. FDA Approves First 3-D Printed Drug. Tech. August 4, 2015. (Accessed 12- june-2017)

Tom Schneider, Emily Apel, Peter Brost, et al. 3D Printing: Perception, Risks, and Opportunities. SSRN. 2014 Nov. (Accessed 12- june-2017)

Wohlar report 2017 (Accessed 25- Oct-2017)

ZipDose Technology; A revolution in formulation; Aprecia pharmaceuticals. (Accessed 12- june-2017)

3D Printing; Aprecia Pharmaceuticals. 12- june-2017

3D PRINTING.COM; What is 3D printing? How does 3D printing work? (Accessed 12- june-2017)

How to Cite
Mazhar, M. and Tariq, U. 2019. Three dimensional (3D) drug printing: A revolution in pharmaceutical science. PharmaTutor. 7, 3 (Mar. 2019), 19-25. DOI: