Anaphylactic Shock: Shocking Error of Immune System!
Keywords:
Anaphylactic Shock, hypersensitivity, IgE-antibodies
Abstract
Activation of immune response is developed in respect to some xenobiotic sensitization, which is supposed to prevent and protect the body from sufferings induced by these xenobiotic. But unfortunately sometime body behaves in a paradoxical manner which misguides the immune system and ultimately turned into a bizarre situation of immune function. One of such response is anaphylactic shock, which is quite fatal if untreated. This review brings insights into the molecular physiology of anaphylactic shock and how some people elicit allergic response to certain substances but not the other. This major catastrophe of the body holds an error of immune system whereas this commentary based review disclosed the synchronization of the unfortunate lessons of the immune system, which makes it a cruel to cause DEATH!
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2. Negi A, Koul S, Gupta P, Garg P, Kumar R: Cystathionine β Lyase like Protein with Pyridoxal Binding Domain Characterized in Leishmania Major by Comparative Sequence Analysis and Homology Modelling. 2013.
3. Lichtenstein LM: The immediate allergic response: in vitro separation of antigen activation, decay and histamine release. The Journal of Immunology 1971, 107 (4); 1122-1130.
4. Sicherer SH, Leung DY: Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. Journal of allergy and clinical immunology 2007, 119 (6); 1462-1469.
5. Akdis CA, Blaser K: Histamine in the immune regulation of allergic inflammation. Journal of allergy and clinical immunology 2003, 112 (1); 15-22.
6. Ogawa Y, Grant JA: Mediators of anaphylaxis. Immunology and allergy clinics of North America 2007, 27 (2); 249-260.
7. Williams CM, Galli SJ: The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. Journal of Allergy and Clinical Immunology 2000, 105 (5); 847-859.
8. R Naik S, M Wala S: Inflammation, Allergy and Asthma, Complex Immune Origin Diseases: Mechanisms and Therapeutic Agents. Recent patents on inflammation & allergy drug discovery 2013, 7 (1); 62-95.
9. Josephs DH, Spicer JF, Corrigan CJ, Gould HJ, Karagiannis SN: Epidemiological associations of allergy, IgE and cancer. Clinical & Experimental Allergy 2013, 43 (10); 1110-1123.
10. Jackson AD: Airway goblet-cell mucus secretion. Trends in pharmacological sciences 2001, 22 (1); 39-45.
11. Solley G, Gleich G, Jordon R, Schroeter A: The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies. Journal of Clinical Investigation 1976, 58 (2); 408.
12. Pumphrey R: Lessons for management of anaphylaxis from a study of fatal reactions. Clinical and experimental allergy 2000, 30 (8); 1144-1150.
13. Trocme SD, Gleich GJ, Kephart GM, Zieske JD: Eosinophil granule major basic protein inhibition of corneal epithelial wound healing. Investigative ophthalmology & visual science 1994, 35 (7); 3051-3056.
14. Romagnani S: Cytokines and chemoattractants in allergic inflammation. Molecular immunology 2002, 38 (12); 881-885.
15. Kinet J-P: The high-affinity IgE receptor (FcεRI): from physiology to pathology. Annual review of immunology 1999, 17 (1); 931-972.
16. Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 1998, 392 (6673); 245-252.
17. Sicherer SH, Leung DY: Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insect stings. Journal of allergy and clinical immunology 2004, 114 (1); 118-124.
18. Robbie-Ryan M, Brown M: The role of mast cells in allergy and autoimmunity. Current opinion in immunology 2002, 14 (6); 728-733.
19. Simons F, Frew AJ, Ansotegui IJ, Bochner BS, Golden DB, Finkelman FD, Leung DY, Lotvall J, Marone G, Metcalfe DD: Risk assessment in anaphylaxis: current and future approaches. Journal of allergy and clinical immunology 2007, 120 (1); S2-S24.
20. Worm M, Babina M, Hompes S: Causes and risk factors for anaphylaxis. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 2013, 11 (1); 44-50.
21. Kemp SF, Lockey RF: Anaphylaxis: a review of causes and mechanisms. Journal of allergy and clinical immunology 2002, 110 (3); 341-348.
22. Simons FER, Ardusso LR, Dimov V, Ebisawa M, El-Gamal YM, Lockey RF, Sanchez-Borges M, Senna GE, Sheikh A, Thong BY: World Allergy Organization Anaphylaxis Guidelines: 2013 Update of the Evidence Base. International archives of allergy and immunology 2013, 162 (3); 193-204.
23. Brown SG, Stone SF, Fatovich DM, Burrows SA, Holdgate A, Celenza A, Coulson A, Hartnett L, Nagree Y, Cotterell C: Anaphylaxis: Clinical patterns, mediator release, and severity. Journal of allergy and clinical immunology 2013.
24. Juel J: Cardiac arrest due to anaphylactic shock: case report. Reactions 2013, 1467; 36-31.
25. Barach EM, Nowak RM, Lee TG, Tomlanovich MC: Epinephrine for treatment of anaphylactic shock. JAMA: the journal of the American Medical Association 1984, 251 (16); 2118-2122.
26. Pushparaj PN, Tay HK, H'ng SC, Pitman N, Xu D, McKenzie A, Liew FY, Melendez AJ: The cytokine interleukin-33 mediates anaphylactic shock. Proceedings of the National Academy of Sciences 2009, 106 (24); 9773-9778.
27. Cui H, Okamoto Y, Yoshioka K, Du W, Takuwa N, Zhang W, Asano M, Shibamoto T, Takuwa Y: Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. Journal of Allergy and Clinical Immunology 2013.
Published
2013-12-01
How to Cite
[1]
Negi, A. 2013. Anaphylactic Shock: Shocking Error of Immune System!. PharmaTutor. 1, 2 (Dec. 2013), 12-16.
Section
Articles
