Indole Based Alkaloid in Cancer: An Overview
Abstract
Indole alkaloids are well characterized for diverse activities. Meanwhile, the present scenario of disease depicting a different story, urge a call for novel scaffolds and pharmacophores. In recent years, indole based alkaloids gain significant importance in cancer chemotherapy and used as an adjuvant especially in case of Vinca alkaloids. These reports encourage the researchers for new finding related to indole based alkaloids to retrieve better scaffold for designing and synthesis of anticancer agents. However we tried to compile the literatures which cover the recent reports and updates of indole based alkaloids targeting in cancer. Moreover this review paper brings new dimension and interface between the indole based alkaloids and their valuable commitment towards cancer targeting.
References
2. Toyota M, Ihara M: Recent progress in the chemistry of non-monoterpenoid indole alkaloids. Natural product reports, 1998, 15 (4): 327-340.
3. Ihara M, Fukumoto K: Recent progress in the chemistry of non-monoterpenoid indole alkaloids. Natural product reports, 1995, 12 (3): 277-301.
4. Hibino S, Choshi T: Simple indole alkaloids and those with a nonrearranged monoterpenoid unit. Natural product reports, 2001, 18 (1): 66-87.
5. Hibino S, Choshi T: Simple indole alkaloids and those with a nonrearranged monoterpenoid unit. Natural product reports, 2002, 19 (2): 148-180.
6. DeVita VT, SERPICK AA, CARBONE PP: Combination chemotherapy in the treatment of advanced Hodgkin's disease. Annals of Internal Medicine, 1970, 73 (6): 881-895.
7. Jordan MA, Thrower D, Wilson L: Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer research, 1991, 51 (8): 2212-2222.
8. Jordan MA, Wilson L: Microtubules as a target for anticancer drugs. Nature Reviews Cancer, 2004, 4 (4): 253-265.
9. Karim AK, Asmara W: Cytotoxic Activity of Tegari (Dianella nemorosa Lam.) Methanol Extract Against HeLa Cells. Indonesian Journal of Biotechnology, 2012, 17 (1).
10. Rani P, Kainsa S, Kumar P: Medicinal plants of Asian origin having anticancer potential: short review. Asian Journal of Biomedical and Pharmaceutical Sciences, 2012, 2 (10): 1-7.
