Invitro and In Vivo Evaluation of Anticancer Activity of Boerhaavia Diffusa Linn in Experimental Animals
Keywords:
Boerhaavia diffusa linn, Antitumor activity, Dalton’s Ascetic Lymphoma Cell line
Abstract
The antitumor activity of the ethanolic extract of leaves of boerhaavia diffusa L. (EBD) has been evaluated against Dalton’s ascitic lymphoma (DAL) in Swiss albino mice at the dose of 250 & 500 mg/kg, body weight. The experimental parameters used were tumour volume, tumour cell count, viable tumour cell count, mean survival time and increase in life span to assess antitumour activity. The extract administered orally for 14 consecutive days to tumor bearing group of animals. The extract increase the life span of DAL treated mice and restore the hematological parameters as compared with the DAL bearing mice in dose dependant manner. The study revealed that the EBD showed significant antitumour activity in tested animal models.
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2. Manu K, Kuttan G, effect of punarnavine , an alkaloid from boerhaavia diffusa linn, on cell mediated immune response and TIMP-1 in B16F-10 metastatic malonema bearing mice, Immunopharmacology and immunutoxicology, 2007, 29,3(4),569-585.
3. AR Mahesh, Harish Kumar, Ranganath MK and Raviraj Anand Devkar, Detail Study on Boerhaavia Diffusa Plant forits Medicinal Importance- A Review, Research Journal of Pharmaceutical Sciences, Vol. 1(1), 28-36, September (2012).
4. Kuldeep Rajpoot, R. N. Mishra, Boerhaavia diffusa roots (Punarnava mool) – Review as Rasayan (Rejuvenator / Antiaging), International Journal of Research in Pharmaceutical and Biomedical Sciences, Vol. 2(4) Oct - Dec 2011.
5. Mother Herbs and Agro Products, motherherbs.com/boerhaavia-diffusa.html.
6. Gothoskar S.V, Ranadive K.J. Anticancer screening of SAN-AB; an extract of marking nut,Semicarpus anacardium, Indian Journal of Experimental Biology, 1971, 9, 372-375.
7. Babu T.D, Kuttan G, Padikkala J. Cytotoxic and antitumor property of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban. Journal of Ethnopharmacology, 1995, 48, 53–57.
8. Tandon V.R, Khajuria V, Kapoor B, Kour D, Gupta S. Hepatoprotective activity of Vitex negundo leaf extract against anti-tubercular drugs induced hepatotoxicity. Fitoterapia, 2008, 79, 533–538.
9. Mazumder U.K, Gupta M, Maiti S, Mukherjee M. Antitumor activity of Gygrophila spinosa onEhrlich ascites carcinoma and sarcoma-180 induced mice. Indian Journal of Experimental Biology, 1997, 35, 473-477.
10. Sur P and Ganguly D.K. Tea plant root extract (TRE) as an antineoplastic agent. Planta Med, 1994, 60, 106-109.
11. Dacie JV, Lewis SM. Practical Hematology. 2nd ed. J and A Churchill, London. 1958. p. 38-48.
12. D’Armour F.E, Blood F.R and Belden D.A. (The Manual for Laboratory Work in MammalianPhysiology. 3rd ed. The University of Chicago Press, Illinois. 1965. p.4-6.
13. Tiwari O.P, Tripathi Y.B. Antioxidant properties of different fractions of Vitex negundo Linn. Food Chemistry, 2007, 100, 1170–1176.
Published
2014-05-01
How to Cite
[1]
Kayande, N. and Kushwah, P. 2014. Invitro and In Vivo Evaluation of Anticancer Activity of Boerhaavia Diffusa Linn in Experimental Animals. PharmaTutor. 2, 5 (May 2014), 133-137.
Section
Articles
